DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnk and tk2

DIOPT Version :9

Sequence 1:	NP_001262722.1	Gene:	dnk / 42273	FlyBaseID:	FBgn0022338	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001002743.2	Gene:	tk2 / 437016	ZFINID:	ZDB-GENE-040718-243	Length:	268	Species:	Danio rerio

Alignment Length:	222	Identity:	100/222 - (45%)
Similarity:	149/222 - (67%)	Gaps:	7/222 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPK 74
            |..:..||.:. .:.:||||.|||||.|.:|.| .:||.:|||||.|||||.|.|.|.|||:||.
Zfish    50 KLVRNGEGKKS-VICLEGNIASGKTTCLEYFSK-TSDIEVLTEPVSKWRNVQGCNPLGLMYQDPT 112

  Fly    75 KWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFI 139
            :|.:..|:||.||||..|.:|....:::|||||:||:|.||||:.::|.:.:..:..|.||:::|
Zfish   113 RWGLTLQTYVQLTMLDQHVSPMTAPIRMMERSIYSAKYIFVENLYKSGKMPEVDFAVLSEWFEWI 177

  Fly   140 EESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRR---PQSCK 201
            .::|.:..|||:||:|||:..:||::||.|.||..:||:||:.:|.|:|||||||:.   |  ..
Zfish   178 IKNISLPVDLIVYLQTSPQTCHERLKQRCREEEKVIPLEYLESIHNLYEDWLIHQKSFHVP--AP 240

  Fly   202 VLVLDADLNLENIGTEYQRSESSIFDA 228
            |||:.||.:|:.:..:::.:...|..|
Zfish   241 VLVIPADHDLKKMLHQFEENREKILMA 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnk	NP_001262722.1	dNK	23..214	CDD:238836	95/193 (49%)
dnk	NP_001262722.1	DTMP_kinase	23..214	CDD:161676	95/193 (49%)
tk2	NP_001002743.2	dNK	62..265	CDD:279974	95/205 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578442
Domainoid	1	1.000	199	1.000	Domainoid score	I3014
eggNOG	1	0.900	-	-		E1_COG1428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3392
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3725
OMA	1	1.010	-	-		QHG54257
OrthoDB	1	1.010	-	-		D1505356at2759
OrthoFinder	1	1.000	-	-		FOG0001503
OrthoInspector	1	1.000	-	-		oto39645
orthoMCL	1	0.900	-	-		OOG6_102194
Panther	1	1.100	-	-	LDO	PTHR10513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4541
SonicParanoid	1	1.000	-	-		X6020
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840