Protein Alignment CG42613 and Cubn

DIOPT Version :10

• Sequence 1: NP_001247185.1
• Gene: CG42613 / 42269
• FlyBaseID: FBgn0261262
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001074553.1
• Gene: Cubn / 65969
• MGIID: 1931256
• Length: 3623
• Species: Mus musculus
• Alignment Length: 972
• Identity: 233/972 - (23%)
• Similarity: 364/972 - (37%)
• Gaps: 251/972 - (25%)

  Fly   215 QKFARSIFPLVI--IFNLLPLFYAGGAHLKSNGADGEPWMQPVVAYLEVSSRPTKSPKCDQTFVS 277
            :||..:..|..|  ::|:|.:.:...:.:::.|            ::.:.|  ::..:|.:....
Mouse   888 EKFCGTNIPSFITSVYNVLYVTFVKSSSMENRG------------FMAMFS--SEKLECGKVLTE 938

  Fly   278 RIGGPQNGSFSAPLLHNHRNHSRQCLYTFLAGPGQRVEVVFKSFNLRGSPPDGSAVGELPSCVHE 342
                 ..|...:|...|.......|.:..:...||.:.:||.||.|...          .:|.::
Mouse   939 -----STGIIESPGHPNVYPSGVNCTWHIVVQRGQLIRLVFSSFYLEFH----------YNCAND 988

  Fly   343 YMDIYSEVQSSEPAELINSPFGGRYCG-TIPPRRRISMYRAVAISFFSNKNVTTDLFEGTFRFIN 406
            |:::|..:..:..         ||||| :|||....|.: ::.:.|.|:..:..:.|...:..||
Mouse   989 YLEVYDTIAQTSL---------GRYCGKSIPPSLTSSSH-SIKLIFVSDSALAHEGFSINYEAIN 1043

  Fly   407 ASEYEIGIPIAGSPCSYTITPSMSVNKTGALISPTYPGAYPKDMSCTYQFLGESNQRVRLEFRDF 471
            ||          |.|.|..|.:.     |.|.||.:|..||.:.:|.|:.....||::.|.|.||
Mouse  1044 AS----------SVCLYDYTDNF-----GRLSSPNFPNNYPHNWNCVYRITVGLNQQIALHFTDF 1093

  Fly   472 DL--FFGGPHCPFDYVKVYDGPDNSSALIGTYCGQQRNLVLYSSESSLFVHFYTLSRTANTQNRG 534
            .|  :| ||.| .|:|::.||...:|.|||.|||......:.|..:.|::.|  .|.||.|. ||
Mouse  1094 ALEDYF-GPKC-VDFVEIRDGGFETSPLIGIYCGSVFPPRIISHSNKLWLRF--KSDTALTA-RG 1153

  Fly   535 FKGIYEFSESFVKLDFIRENDGIHIRGSECDQKILSKKESTGFVLSPNYPYPYIPKTVCRYFIYG 599
            |...::.|                  .:.|...:.:   .||.:.|||||.||...:.|    |.
Mouse  1154 FSAYWDAS------------------STGCGGNLTT---PTGVLTSPNYPMPYYHSSEC----YW 1193

  Fly   600 MQDAQHLERVRLEFNAFNIPKVEHKDKSESNCTDGYLKIYLKGQETADAYDKFDYELCGNETQRV 664
            ..:|.......|||..|::   ||    ..||:..||.:: .|..|   ..:...:|||:.....
Mouse  1194 RLEASRGSPFLLEFQDFHL---EH----HPNCSLDYLAVF-DGPST---NSRLINKLCGDTPPAP 1247

  Fly   665 ISEGPRLAMV---FSSGELQGRGFKGKYTFETEYKIPGTAAPDGTCSFTYVSSSKKRGELNSPRY 726
            |.....:.::   ..:|: ||||      ||..|:        .||. ..|..:|..|.|.|..|
Mouse  1248 IRSSKDIVLLKLRTDAGQ-QGRG------FEINYR--------QTCD-NVVIVNKTSGILESINY 1296

  Fly   727 PSNYPSDTNCSYLFLAEADEQVTIVFDHFKIKADNNANATAGAYGSGACFEDWLEMYVVYRDNND 791
            |:.|..|..|::...|.....|...|..|.:  :|..|          |..|:||:|    |...
Mouse  1297 PNPYDKDQRCNWTIQATTGNTVNYTFLEFDV--ENYVN----------CSTDYLELY----DGPQ 1345

  Fly   792 RLLGRYCGQTAPGPVESPRGAV---GLRITLHTD-QESVASGFKARYFFESAKSDAGDCGGNFSN 852
            | :|||||:..|     |.||.   .|.:..||| .:|...|||..:|...       |||..|.
Mouse  1346 R-IGRYCGENIP-----PPGATTGSKLIVVFHTDGVDSGEKGFKMHWFIHG-------CGGEMSG 1397

  Fly   853 QDSGLITSPNWPAGYKAPGRGMASNACNWVMKARPGYKLSIHFEQFGLEGDPANRGCPAAVLRLW 917
             ..|..:||.:|..|.      .:..|.|.::..||..:.:....|.:|   .:..|....|.::
Mouse  1398 -TMGSFSSPGYPNSYP------HNKECIWNIRVAPGNSIQLTIHDFDVE---YHASCKYDTLEIY 1452

  Fly   918 MNVDSDQPPL-ELCGEKPPVEQWHYTSTGQTARISFTTSDKTVGAQGFRIVWTEIQDSGPGPPSV 981
            ..:|...|.: :||...|.......:||.....|.|.| |.::..:||...|..:    ||
Mouse  1453 TGLDFHSPRIAQLCSRSPSANPMQISSTDNELAIRFKT-DSSLNGRGFNASWRAV----PG---- 1508

  Fly   982 GLHCESTYHFQCGAGYCISDKLRCDGVKNCGPGDDTDELH---------CTTEAA-----EEDYD 1032
                                  .|.|:.....|    |:|         ..||.:     |:.:.
Mouse  1509 ----------------------GCGGIFQVSRG----EIHSPNYPNNYRANTECSWIIQVEKYHR 1547

  Fly  1033 VLIIIT---LLVVSSLICLL------------CILCHSRRSRRNHVRQLGLHRNAHYDSQTSATA 1082
            ||:.||   |....|  ||:            ..:| .|:...|.:...|......:.|.:|:.:
Mouse  1548 VLLNITDFDLEATDS--CLMTYDGSSSANTRVATVC-GRQQPPNSITSSGNSLFVRFQSGSSSQS 1609

  Fly  1083 GLSSSRRHLQSGGASIAGSLHGINSGNLIIPPAPLPPTSVP-----------PPP--HICIA 1131
            ....::...:.|...|..|...|:|        ||.|.:.|           .||  ||.::
Mouse  1610 RGFRAQFRQECGAHIITDSSDSISS--------PLYPANYPNNQNCTWIIEAQPPFNHIALS 1663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42613	NP_001247185.1	CUB	277..404	CDD:238001	26/127 (20%)
		CUB	421..541	CDD:238001	44/121 (36%)
		CUB	564..691	CDD:238001	34/129 (26%)
		CUB	707..836	CDD:238001	41/132 (31%)
		CUB	846..969	CDD:238001	30/123 (24%)
		LDLa	987..1022	CDD:238060	5/43 (12%)
Cubn	NP_001074553.1	cubilin_NTD	38..132	CDD:412063
		Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494	39..46
		EGF_CA	133..164	CDD:238011
		EGF_CA	167..207	CDD:238011
		EGF_CA	260..301	CDD:214542
		EGF_3	306..344	CDD:463759
		EGF_3	350..387	CDD:463759
		EGF_CA	400..430	CDD:238011
		EGF_CA	432..468	CDD:238011
		CUB	474..585	CDD:238001
		CUB	590..699	CDD:238001
		CUB	708..815	CDD:238001
		CUB	817..927	CDD:238001	8/52 (15%)
		CUB	932..1041	CDD:238001	27/133 (20%)
		CUB	1052..1158	CDD:238001	42/115 (37%)
		CUB	1165..1275	CDD:238001	36/134 (27%)
		CUB	1278..1388	CDD:238001	41/132 (31%)
		CUB	1391..1505	CDD:238001	31/124 (25%)
		CUB	1510..1599	CDD:238001	20/95 (21%)
		CUB	1620..1733	CDD:238001	13/52 (25%)
		CUB	1738..1847	CDD:238001
		CUB	1859..1962	CDD:238001
		CUB	1978..2089	CDD:238001
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3623	CDD:238001