Protein Alignment Sgsh and ARSJ

DIOPT Version :10

• Sequence 1: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_078866.3
• Gene: ARSJ / 79642
• HGNCID: 26286
• Length: 599
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 114/568 - (20%)
• Similarity: 197/568 - (34%)
• Gaps: 206/568 - (36%)

  Fly    17 SAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAG 81
            |....:::.:||||.||....|.....:||.||.||..|:...|.:.. ..|:|||||.:||:
Human    72 STSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK-- 133

  Fly    82 HSSGMYGLHQGV-HNF------NVLP-DTGSLPNLIRDQSGGRILSGIIGKKHVG---------- 128
                 |.:|.|: |:.      |.|| |..:||..:::..   ..:.::||.|:|
Human   134 -----YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVG---YSTHMVGKWHLGFYRKECMPTR 190

  Fly   129 ---------------------------------AANNFRFDFEQTEEQHSINQIGRNITRMKEYA 160
                                             ..:|..:|::.          |...|:|....
Human   191 RGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDN----------GIYSTQMYTQR 245

  Fly   161 RQFLKQAKDEKKPFFLMVGF---HDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRN 222
            .|.:..:.:..||.||.:.:   |.|.:..      |.:.|.:.|
Human   246 VQQILASHNPTKPIFLYIAYQAVHSPLQAP------GRYFEHYRS-------------------- 284

  Fly   223 LDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP-------- 279
                    ..::.|:..||.   :|.||:.:..:...|:..|..:.:::||:||||.
Human   285 --------IININRRRYAAM---LSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSN 338

  Fly   280 -PFPGGRTNLYEHGIRSPLIISSP---NKEDRHHEATAAMVSLLDIYPSVMDALQIPRPNDTKIV 340
             |..|.:...:|.|||:...:.||   ||.....|    :|.:.|.||:::...:.....|.::.
Human   339 WPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKE----LVHITDWYPTLISLAEGQIDEDIQLD 399

  Fly   341 GRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPIDQDFYTSP 405
            |..|...:.|.                          :|:.|..::|||:     ||    ||..
Human   400 GYDIWETISEG--------------------------LRSPRVDILHNID-----PI----YTKA 429

  Fly   406 ----------TFQQILNATLRKQ-------------TLP-----------WYRSLLQYYQRPEWE 436
                      .:...:.:.:|.|             .:|           |:...:.........
Human   430 KNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVW 494

  Fly   437 LYDIKTDPLERFNLADKAKYNGTLKQLREQLFDW-------QVATKDP 477
            |::|..||.||.:|::  :|.|.:|:|..:|..:       :...|||
Human   495 LFNITADPYERVDLSN--RYPGIVKKLLRRLSQFNKTAVPVRYPPKDP 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	110/555 (20%)
ARSJ	NP_078866.3	4-S	76..509	CDD:293753	104/529 (20%)
		DUF4976	<495..>533	CDD:419068	12/39 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..599		3/10 (30%)