DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sgsh and ARSJ

DIOPT Version :9

Sequence 1:NP_650760.1 Gene:Sgsh / 42266 FlyBaseID:FBgn0038660 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_078866.3 Gene:ARSJ / 79642 HGNCID:26286 Length:599 Species:Homo sapiens


Alignment Length:568 Identity:114/568 - (20%)
Similarity:197/568 - (34%) Gaps:206/568 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAG 81
            |....:::.:||||.||....|.....:||.||.||..|:...|.:.. ..|:|||||.:||:  
Human    72 STSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK-- 133

  Fly    82 HSSGMYGLHQGV-HNF------NVLP-DTGSLPNLIRDQSGGRILSGIIGKKHVG---------- 128
                 |.:|.|: |:.      |.|| |..:||..:::..   ..:.::||.|:|          
Human   134 -----YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVG---YSTHMVGKWHLGFYRKECMPTR 190

  Fly   129 ---------------------------------AANNFRFDFEQTEEQHSINQIGRNITRMKEYA 160
                                             ..:|..:|::.          |...|:|....
Human   191 RGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDN----------GIYSTQMYTQR 245

  Fly   161 RQFLKQAKDEKKPFFLMVGF---HDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRN 222
            .|.:..:.:..||.||.:.:   |.|.:..      |.:.|.:.|                    
Human   246 VQQILASHNPTKPIFLYIAYQAVHSPLQAP------GRYFEHYRS-------------------- 284

  Fly   223 LDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP-------- 279
                    ..::.|:..||.   :|.||:.:..:...|:..|..:.:::||:||||.        
Human   285 --------IININRRRYAAM---LSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSN 338

  Fly   280 -PFPGGRTNLYEHGIRSPLIISSP---NKEDRHHEATAAMVSLLDIYPSVMDALQIPRPNDTKIV 340
             |..|.:...:|.|||:...:.||   ||.....|    :|.:.|.||:::...:.....|.::.
Human   339 WPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKE----LVHITDWYPTLISLAEGQIDEDIQLD 399

  Fly   341 GRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPIDQDFYTSP 405
            |..|...:.|.                          :|:.|..::|||:     ||    ||..
Human   400 GYDIWETISEG--------------------------LRSPRVDILHNID-----PI----YTKA 429

  Fly   406 ----------TFQQILNATLRKQ-------------TLP-----------WYRSLLQYYQRPEWE 436
                      .:...:.:.:|.|             .:|           |:...:.........
Human   430 KNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVW 494

  Fly   437 LYDIKTDPLERFNLADKAKYNGTLKQLREQLFDW-------QVATKDP 477
            |::|..||.||.:|::  :|.|.:|:|..:|..:       :...|||
Human   495 LFNITADPYERVDLSN--RYPGIVKKLLRRLSQFNKTAVPVRYPPKDP 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SgshNP_650760.1 AslA 17..476 CDD:225661 111/565 (20%)
SGSH 22..471 CDD:293751 110/555 (20%)
ARSJNP_078866.3 4-S 76..509 CDD:293753 104/529 (20%)
DUF4976 <495..>533 CDD:328073 12/39 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 531..599 3/10 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3119
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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