DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and sgsh

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001116740.1	Gene:	sgsh / 563849	ZFINID:	ZDB-GENE-030131-4958	Length:	511	Species:	Danio rerio

Alignment Length:	502	Identity:	256/502 - (50%)
Similarity:	338/502 - (67%)	Gaps:	25/502 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IAGCSAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLT 77
            :.||.:  :||||::|||.|||:..|.|...|||:|.||:||.|:|.||||||||||||||.:||
Zfish    18 VGGCRS--RNVLLIIADDGGFETDVYNNTVVQTPHLRALSKRSLIFKNAFTSVSSCSPSRSTILT 80

  Fly    78 GQAGHSSGMYGLHQGVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFRFDFEQTEE 142
            |...|.:||||||||||:||......|||.|::   ...|.:|||||||||....:.|||..|||
Zfish    81 GLPQHQNGMYGLHQGVHHFNSFDGVQSLPLLLK---RANIHTGIIGKKHVGPGPVYPFDFAYTEE 142

  Fly   143 QHSINQIGRNITRMKEYARQFLKQAKDEK------KPFFLMVGFHDPHRCGHITPQFGEFCERWG 201
            .:|:.|:|||||::|...|:|.:..|:|:      :||||.|.|||||||||..||:|.|||::|
Zfish   143 TNSVLQVGRNITKIKLLVRKFFQSHKEERSETKEERPFFLYVAFHDPHRCGHSQPQYGVFCEKFG 207

  Fly   202 SGEEGMGSIPDWKPIYYDWRNLDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVA 266
            :||.|||.||||:|.||....:.||.::|||...|.::||||.|:||||||:||:|:||..||..
Zfish   208 NGESGMGRIPDWEPKYYSPDQVKVPYFIPDTPAARADIAAQYTTVSRLDQGIGLVLEELRKAGFE 272

  Fly   267 DQTLVIYTSDNGPPFPGGRTNLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQI 331
            :.|||||:||||.|||.||||||..|::.|:::|||..:.|..:.:.|.||||||.|:::|...:
Zfish   273 NDTLVIYSSDNGIPFPNGRTNLYGSGVKEPMLLSSPEHQQRWGKLSQAYVSLLDITPTILDWFSL 337

  Fly   332 PRPN-------DTKIVGRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNI 389
            |.|:       ..::.|||:||.|..||   ..|:||.|.|.|||||.||||.:....|:|:||:
Zfish   338 PYPSYSLSMSQPVELTGRSLLPALISEP---SWDTVFSSQSLHEVTMFYPMRSIHKGPYRLLHNL 399

  Fly   390 NYWADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEWELYDIKTDPLERFNLADKA 454
            :|...||||||||.|||||.:||.|...:...|:::|.:||.|..|||:|::|||:|:.|||...
Zfish   400 HYRMPFPIDQDFYISPTFQDLLNRTQSGRPTGWFKTLNEYYYRQRWELFDVRTDPMEKVNLAGDL 464

  Fly   455 KYNGTLKQLREQLFDWQVATKDPWRCAPHAVLQEQGVYKDQPVCLTL 501
            .|:..|:.|::.|..||..|:|||.|.|.|||:.    |.:|.|..|
Zfish   465 DYSEVLESLKDLLLKWQWRTEDPWVCEPDAVLEA----KLEPECRPL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	242/471 (51%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	239/461 (52%)
sgsh	NP_001116740.1	SGSH	25..481	CDD:293751	239/461 (52%)
sgsh	NP_001116740.1	AslA	25..461	CDD:225661	233/441 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585532
Domainoid	1	1.000	358	1.000	Domainoid score	I929
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H167
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1266
OMA	1	1.010	-	-		QHG63124
OrthoDB	1	1.010	-	-		D194238at33208
OrthoFinder	1	1.000	-	-		FOG0007960
OrthoInspector	1	1.000	-	-		oto40147
orthoMCL	1	0.900	-	-		OOG6_107938
Panther	1	1.100	-	-	LDO	PTHR43108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5386
SonicParanoid	1	1.000	-	-		X5904
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800