DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and ids

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001073537.1	Gene:	ids / 559959	ZFINID:	ZDB-GENE-061215-37	Length:	561	Species:	Danio rerio

Alignment Length:	607	Identity:	141/607 - (23%)
Similarity:	225/607 - (37%)	Gaps:	208/607 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQWIFTLWL-----------IAGCSAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLL 57
            :.::||.|.           :....:...|||.|:|||.....|.|.:...::||:|.||...::
Zfish     3 VMFVFTCWWFVFIFHLLGRDVFAAKSKNFNVLYLIADDLRPTLGCYSDPVVKSPNIDQLASLSVV 67

  Fly    58 FNNAFTSVSSCSPSRSQLLTGQAGHSSGMYG------LHQGVHNFNVLPDTGSLPNLIRDQSGGR 116
            |:||:...:.|.|||...||.:...::.:|.      :|.|  |:..||.       ....:|..
Zfish    68 FHNAYAQQAVCGPSRVSFLTSRRPDTTKLYDFNSYWRVHAG--NYTTLPQ-------YFKSNGYT 123

  Fly   117 ILSGIIGKK-HVGAANNF----------------RFDFEQTE-------EQHSINQIGRNITRM- 156
            .||  :||. |.|.|:|.                .|::|:.:       ..||......|::.|
Zfish   124 TLS--VGKVFHPGIASNHSDDYPYSWSVPPYHPPSFEYEKRKVCKDKDGTLHSNLLCPVNVSEMP 186

  Fly   157 ---------KEYARQFLKQAKDEKKPFFLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPD 212
                     .|.|.:.|:..|..:|||||.|||:.||....| ||  |:.:.:..  |.|...||
Zfish   187 LGTLPDMENTEEAIRLLRSMKGSQKPFFLSVGFYKPHIPFRI-PQ--EYLKLYPI--ENMTLAPD 246

  Fly   213 WKPIYYDWRNLDVPAWLPD------TDVVRQE------LAAQY----------------MTISRL 249
              |        |||..|||      ||:.::|      |:..|                .::|.:
Zfish   247 --P--------DVPKKLPDVAYNPWTDIRKREDVQALNLSFPYGPIPKDFQLRIRQHYFASVSYV 301

  Fly   250 DQGVGLMLKELEAAGVADQTLVIYTSDNGPPFPGGRTNLYEHG-----------IRSPLII---- 299
            |..||.:|:.|:..|:|..|:|:.:||:|       .:|.|||           .|.||::
Zfish   302 DAQVGKILQTLDDVGLAKNTIVVLSSDHG-------WSLGEHGEWAKYSNFDVATRVPLMVYKAG 359

  Fly   300 -----SSPN----------KEDRHH----EATAAMVSLLDIYPSVMDALQIPRPN---------D 336
                 |.|.          ::.|.|    :...::|.|||::|::.:...:|..:         |
Zfish   360 VSSRRSRPGAKTFPFIDVFQDTREHFGKGKIVNSVVELLDVFPTLANLAGLPSVHHCPSPSFKMD 424

  Fly   337 TKIVGRSILPVLREEPPI-----------KESDSVFGSHSYHEVT----MAYPMRMVRNRRYKLI 386
            ....|.::..::|....:           :.|||:..:.....:.    |.|.:|. .:.||.|
Zfish   425 LCTEGSNLANLIRNPKHLNREAYSFSQYPRPSDSIQENSDLPNLADIRIMGYSIRS-NDYRYTL- 487

  Fly   387 HNINYWADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEWELYDIKTDPLERFNLA 451
                 |..|   ...:..|...:|                      ...|||.:..||.:..||.
Zfish   488 -----WVGF---DPLHCKPNMTEI----------------------HAGELYILTEDPGQDNNLF 522

  Fly   452 DK----AKYN--GTLKQLREQL 467
            |:    |..|  ||:....|.|
Zfish   523 DEFGHAALLNKFGTMPSWTESL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	138/583 (24%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	138/578 (24%)
ids	NP_001073537.1	iduronate-2-sulfatase	29..527	CDD:293754	132/562 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810