DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgsh and Arsi

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001033588.1	Gene:	Arsi / 545260	MGIID:	2670959	Length:	573	Species:	Mus musculus

Alignment Length:	546	Identity:	115/546 - (21%)
Similarity:	193/546 - (35%)	Gaps:	189/546 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSS 84
            |.:::.:|.||.|:....|.....:||.||.||..|:...|.:.. ..|:|||||||||:
Mouse    46 PPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQ-PICTPSRSQLLTGR----- 104

  Fly    85 GMYGLHQGV-HNF------NVLP-DTGSLPNLIRDQSGGRILSGIIGKKHV-------------- 127
              |.:|.|: |:.      |.|| |..:||..:::..   ..:.::||.|:
Mouse   105 --YQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAG---YSTHMVGKWHLGFYRKECLPTRRGF 164

  Fly   128 --------GAANNFRFD---------FEQTE-EQHSINQIGRNITRMKEYARQFLKQAKDEKKPF 174
                    |..:.:.:|         |:..| |..:....|:..|.:.......:..:.:.:.|.
Mouse   165 DTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHNPQNPL 229

  Fly   175 FLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNLDVPAWLPDTDVVRQEL 239
            ||.|.|...|     ||                  :...:...|.:|.:.        :|.|::.
Mouse   230 FLYVAFQAVH-----TP------------------LQSPREYLYRYRTMG--------NVARRKY 263

  Fly   240 AAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP---------PFPGGRTNLYEHGIRS 295
            ||.   ::.:|:.|..:...|:..|..:.:::|::||||.         |..|.:...:|.|:|.
Mouse   264 AAM---VTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRG 325

  Fly   296 PLIISSP--NKEDRHHEATAAMVSLLDIYP----------SVMDALQIPRPNDTKIVGRSILPVL 348
            ...:.||  .|:.|   .:.|:|.:.|.||          |..|.|.          |..:.|.:
Mouse   326 LGFVHSPLLKKKRR---TSRALVHITDWYPTLVGLAGGTTSAADGLD----------GYDVWPAI 377

  Fly   349 REEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNI----NYWADFPIDQDFYTSPTFQQ 409
            .|                   ..|.|       |.:::|||    |:.....::..|   ..:..
Mouse   378 SE-------------------GRASP-------RTEILHNIDPLYNHARHGSLEGGF---GIWNT 413

  Fly   410 ILNATLR------------------KQTLP------WYRSLLQYYQRPEWELYDIKTDPLERFNL 450
            .:.|.:|                  .|||.      |....:...::..| |::|..||.||.:|
Mouse   414 AVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVW-LFNISADPYEREDL 477

  Fly   451 ADK------------AKYNGTLKQLR 464
            |.:            |.||.|...:|
Mouse   478 AGQRPDVVRTLLARLADYNRTAIPVR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	115/546 (21%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	114/544 (21%)
Arsi	NP_001033588.1	AslA	47..492	CDD:225661	109/532 (20%)
		4-S	47..478	CDD:293753	107/518 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900