Protein Alignment Sgsh and ARSA

DIOPT Version :10

• Sequence 1: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000478.3
• Gene: ARSA / 410
• HGNCID: 713
• Length: 509
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 135/518 - (26%)
• Similarity: 196/518 - (37%)
• Gaps: 162/518 - (31%)

  Fly    10 LWLIAGCS-AGPQNVLLLLADDAGF-ESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSR 72
            |.|.||.: |.|.|::|:.|||.|: :.|.|.:....|||||.||..||.|.:.:..||.|:|||
Human    11 LALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSR 75

  Fly    73 SQLLTGQAGHSSGMYGLHQGVHNFNVLPDT-GSLPNLIRDQSGGRI------LSGIIGKKHVGAA 130
            :.||||:.....|||   .||    ::|.: |.||  :.:.:...:      |:|:.||.|:|..
Human    76 AALLTGRLPVRMGMY---PGV----LVPSSRGGLP--LEEVTVAEVLAARGYLTGMAGKWHLGVG 131

  Fly   131 NNFRF--------DFEQTEEQHSINQIGRNIT--------------------------------- 154
            ....|        .|......|..... :|:|
Human   132 PEGAFLPPHQGFHRFLGIPYSHDQGPC-QNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPW 195

  Fly   155 ------RMKEYARQFLKQAKDEKKPFFLMVGFHDPHRCGHITPQFG--EFCERWGSGEEGMGSIP 211
                  |...:|...:..|:.:.:||||....|..|     .|||.  .|.||.|.|..|
Human   196 LPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSFAERSGRGPFG----- 250

  Fly   212 DWKPIYYDWRNLDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSD 276
                                            .::..||..||.::..:...|:.::||||:|:|
Human   251 --------------------------------DSLMELDAAVGTLMTAIGDLGLLEETLVIFTAD 283

  Fly   277 NGPP----FPGGRTNL--------YEHGIRSPLIISSPNKEDRHHEA---TAAMVSLLDIYPSVM 326
            |||.    ..||.:.|        ||.|:|.|.:...|.     |.|   |..:.|.||:.|::.
Human   284 NGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPG-----HIAPGVTHELASSLDLLPTLA 343

  Fly   327 DALQIPRPNDTKIVGRSILPVL---REEPPIKESDSVFGSHSY-HEVTMAYPMRMVRNRRYKLIH 387
            .....|.||.| :.|..:.|:|   .:.|    ..|:|...|| .||...:   .||..:||
Human   344 ALAGAPLPNVT-LDGFDLSPLLLGTGKSP----RQSLFFYPSYPDEVRGVF---AVRTGKYK--- 397

  Fly   388 NINYWADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEWELYDIKTDPLERFNL 450
                 |.|......::..|.....:|:          |.|..::.|  .|||:..||.|.:||
Human   398 -----AHFFTQGSAHSDTTADPACHAS----------SSLTAHEPP--LLYDLSKDPGENYNL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	129/505 (26%)
ARSA	NP_000478.3	ARSA	22..505	CDD:293777	130/507 (26%)