DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and Sulf2

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001030099.1	Gene:	Sulf2 / 311642	RGDID:	1305078	Length:	875	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	119/579 - (20%)
Similarity:	197/579 - (34%)	Gaps:	222/579 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LW--------LIAGCSA---GPQ--------------NVLLLLADDAGFESGA--YLNKFCQTPN 47
            ||        |:||.||   .|:              |::|:|.||...|.|:  .:||   |..
  Rat     8 LWLLSTALFSLLAGSSAFLSYPRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNK---TRR 69

  Fly    48 LDALAKRGLLFNNAFTSVSSCSPSRSQLLTG--------------------QAGHSSGMYGLHQG 92
            :  :.:.|..|.|||.:...|.||||.:|||                    ||.|.|..:.::..
  Rat    70 I--MEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLN 132

  Fly    93 VHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFRFDFEQT------EEQHSINQIGR 151
            ...:.    |......:.:.:|..:..|  .|:.||...|.|| :..|      :|:|.
  Rat   133 STGYR----TAFFGKYLNEYNGSYVPPG--WKEWVGLLKNSRF-YNYTLCRNGMKEKHG------ 184

  Fly   152 NITRMKEYARQFLKQA---------KDEKK-----PFFLMVGFHDPH---------------RCG 187
                 .:|:..:|...         :..||     |..:::....||               ...
  Rat   185 -----SDYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQ 244

  Fly   188 HITPQFGEFCERWGSGEEGMGSIPD--W--------KPIYYDWRNLDVPAWLPDTDVVRQELAAQ 242
            ||||.:            .....||  |        |||:.::.|:          :.|:.|
  Rat   245 HITPSY------------NYAPNPDKHWIMRYTGPMKPIHMEFTNM----------LQRKRL--- 284

  Fly   243 YMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP-----PFPGGRTNLYEHGIRSPLIISSP 302
             .|:..:|..:..:...|...|..|.|.::||:|:|.     ....|::..||..||.|..:..|
  Rat   285 -QTLMSVDDSMETIYDMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGP 348

  Fly   303 NKE----DRHHEATAAMVSLLDIYPSVMD--ALQIPRPNDTKIVGRSILPVLREEPPIKESDSVF 361
            :.|    :.|      :|..:|:.|:::|  .|.||...|    |:|||.:|..|.|:
  Rat   349 SVEAGSLNPH------IVLNIDLAPTILDIAGLDIPADMD----GKSILKLLDSERPV------- 396

  Fly   362 GSHSYHEVTMAYPMRMVRNRRYKLIHNINYWAD-FPIDQDFYTSPTFQQILNATLRKQTLPWYRS 425
                               .|:.|...:..|.| |.:::.        ::|:.....:......:
  Rat   397 -------------------NRFHLKKKLRVWRDSFLVERG--------KLLHKREGDKVNAQEEN 434

  Fly   426 LLQYYQRPEWELYDIKTDPLERFNLADKAKYNGTLKQLREQLFDWQVATKDPWRCAPHA 484
            .|..|||.:              :|..:|:|....:||.::           |:|...|
  Rat   435 FLPKYQRVK--------------DLCQRAEYQTACEQLGQK-----------WQCVEDA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	111/554 (20%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	108/527 (20%)
Sulf2	NP_001030099.1	G6S	43..385	CDD:293766	87/400 (22%)
		DUF3740	533..666	CDD:403667
		ALP_like	<754..803	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810