DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgsh and Arsi

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001041346.1	Gene:	Arsi / 307404	RGDID:	1310242	Length:	573	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	117/546 - (21%)
Similarity:	194/546 - (35%)	Gaps:	189/546 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSS 84
            |.:::.:|.||.|:....|.....:||.||.||..|:...|.:.. ..|:|||||||||:
  Rat    46 PPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQ-PICTPSRSQLLTGR----- 104

  Fly    85 GMYGLHQGV-HNF------NVLP-DTGSLPNLIRDQSGGRILSGIIGKKHV-------------- 127
              |.:|.|: |:.      |.|| |..:||..:::..   ..:.::||.|:
  Rat   105 --YQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAG---YSTHMVGKWHLGFYRKECLPTRRGF 164

  Fly   128 --------GAANNFRFD---------FEQTE-EQHSINQIGRNITRMKEYARQFLKQAKDEKKPF 174
                    |..:.:.:|         |:..| |..:....|:..|.:.......:..:...:||.
  Rat   165 DTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHSPQKPL 229

  Fly   175 FLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNLDVPAWLPDTDVVRQEL 239
            ||.|.|...|     ||                  :...:...|.:|.:.        :|.|::.
  Rat   230 FLYVAFQAVH-----TP------------------LQSPREYLYRYRTMG--------NVARRKY 263

  Fly   240 AAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP---------PFPGGRTNLYEHGIRS 295
            ||.   ::.:|:.|..:...|:..|..:.:::|::||||.         |..|.:...:|.|:|.
  Rat   264 AAM---VTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRG 325

  Fly   296 PLIISSP--NKEDRHHEATAAMVSLLDIYP----------SVMDALQIPRPNDTKIVGRSILPVL 348
            ...:.||  .|:.|   .:.|:|.:.|.||          |..|.|.          |..:.|.:
  Rat   326 LGFVHSPLLKKKRR---TSRALVHITDWYPTLVGLAGGTTSAADGLD----------GYDVWPAI 377

  Fly   349 REEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNI----NYWADFPIDQDFYTSPTFQQ 409
            .|                   ..|.|       |.:::|||    |:.....::..|   ..:..
  Rat   378 SE-------------------GRASP-------RTEILHNIDPLYNHARHGSLEGGF---GIWNT 413

  Fly   410 ILNATLR------------------KQTLP------WYRSLLQYYQRPEWELYDIKTDPLERFNL 450
            .:.|.:|                  .|||.      |....:...::..| |::|..||.||.:|
  Rat   414 AVQAAIRVGEWKLLTGDPGYGDWIPPQTLASFPGSWWNLERMASIRQAVW-LFNISADPYEREDL 477

  Fly   451 ADK------------AKYNGTLKQLR 464
            ||:            |.||.|...:|
  Rat   478 ADQRPDVVRTLLARLADYNRTAIPVR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	117/546 (21%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	116/544 (21%)
Arsi	NP_001041346.1	4-S	48..478	CDD:293753	108/517 (21%)
		AslA	49..485	CDD:225661	111/523 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810