DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and Gns

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006241458.1	Gene:	Gns / 299825	RGDID:	1305877	Length:	544	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	123/538 - (22%)
Similarity:	222/538 - (41%)	Gaps:	134/538 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IFTLWLIAGC-----SAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVS 66
            :..|.|::||     :|...||||||.||...|.|. :....:|..|  :.::|:.|::|:...:
  Rat    20 LLLLPLLSGCLGLVGAARRPNVLLLLTDDQDAELGG-MTPLKKTKAL--IGEKGMTFSSAYVPSA 81

  Fly    67 SCSPSRSQLLTGQAGHSSGMYGLHQGVHN----------FNVLPDTGSLPNLIRDQSG------G 115
            .|.|||:.:|||:..|:      |..|:|          :..:.:..:.|.:::...|      |
  Rat    82 LCCPSRASILTGKYPHN------HHVVNNTLEGNCSSKSWQKIQEPYTFPAILKLVCGYQTFFAG 140

  Fly   116 RIL-------SGIIGKKHVGAANNFRFDFEQTEEQH----SINQIGRNITRMKEYARQFLKQA-- 167
            :.|       :|  |.:||....::.:..|:..:.:    |||  |:.....:.|:..:|...
  Rat   141 KYLNEYGAPDAG--GLEHVPLGWSYWYALEKNSKYYNYTLSIN--GKARRHGENYSVDYLTDVLA 201

  Fly   168 ---------KDEKKPFFLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNL 223
                     |...:|||:|:....||......||:.:             :.|:  .|....:|.
  Rat   202 NLSLDFLDYKSNSEPFFMMISTPAPHSPWTAAPQYQK-------------AFPN--VIAPRNKNF 251

  Fly   224 DVPA----WL------PDT--------DVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTL 270
            ::..    ||      |.|        |..|:    ::.|:..:|..|..::|.|::.|..|.|.
  Rat   252 NIHGTNKHWLIRQAKTPMTNSSIKFLDDAFRR----RWQTLLSVDDLVEKLVKRLDSTGELDNTY 312

  Fly   271 VIYTSDNGP-----PFPGGRTNLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQ 330
            :.||||||.     ..|..:..|||..|:.||::..|.  .:.::.:..:||.:|:.|:::|...
  Rat   313 IFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPG--IKPNQTSKMLVSNIDLGPTILDLAG 375

  Fly   331 IPRPNDTKIVGRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWAD- 394
            ... |.|::.|.|:||:|:.:          |:.::....:.......||.......:::....
  Rat   376 YDL-NKTQMDGTSLLPILKGD----------GNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQ 429

  Fly   395 -FP--IDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEW----ELYDIKTDPLERFNLAD 452
             ||  :.:|.|.: |:     |.:|..:..|.   |||.:..:.    |:|:|..||.:..|:|.
  Rat   430 CFPDCVCEDAYNN-TY-----ACVRTLSSMWN---LQYCEFDDQEVFVEVYNITADPDQITNIAK 485

  Fly   453 K------AKYNGTLKQLR 464
            .      .|.|..|..|:
  Rat   486 SIDPELLGKMNYRLMMLQ 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	119/523 (23%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	118/518 (23%)
Gns	XP_006241458.1	G6S	38..487	CDD:293766	114/502 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810