Protein Alignment Sgsh and GNS

DIOPT Version :10

• Sequence 1: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_002067.1
• Gene: GNS / 2799
• HGNCID: 4422
• Length: 552
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 114/512 - (22%)
• Similarity: 205/512 - (40%)
• Gaps: 117/512 - (22%)

  Fly    10 LWLIAGC------SAGPQ--NVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVS 66
            |.::.||      :||.:  ||:|||.||.....|. :....:|..|  :.:.|:.|::|:...:
Human    28 LLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGG-MTPLKKTKAL--IGEMGMTFSSAYVPSA 89

  Fly    67 SCSPSRSQLLTGQAGHSSGMYGLHQGVHN----------FNVLPDTGSLPNLIRDQSG------G 115
            .|.|||:.:|||:..|:      |..|:|          :..:.:..:.|.::|...|      |
Human    90 LCCPSRASILTGKYPHN------HHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAG 148

  Fly   116 RIL-------SGIIGKKHVGAANNFRFDFEQTEEQH----SINQIGRNITRMKEYARQFLKQA-- 167
            :.|       :|  |.:||....::.:..|:..:.:    |||  |:.....:.|:..:|...
Human   149 KYLNEYGAPDAG--GLEHVPLGWSYWYALEKNSKYYNYTLSIN--GKARKHGENYSVDYLTDVLA 209

  Fly   168 ---------KDEKKPFFLMVGFHDPHRCGHITPQFGE-----FCER------WGSGEEGMGSIPD 212
                     |...:|||:|:....||......||:.:     |..|      .|:.:.
Human   210 NVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKH------- 267

  Fly   213 WKPIYYDW--RNLDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTS 275
                   |  |....|........:......::.|:..:|..|..::|.||..|..:.|.:.|||
Human   268 -------WLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTS 325

  Fly   276 DNGP-----PFPGGRTNLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQIPRPN 335
            |||.     ..|..:..|||..|:.||::..|.  .:.::.:..:|:.:|:.|:::|...... |
Human   326 DNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPG--IKPNQTSKMLVANIDLGPTILDIAGYDL-N 387

  Fly   336 DTKIVGRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFP--ID 398
            .|::.|.|:||:||....:.....|...:......:..|...      .|...::..  ||  :.
Human   388 KTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCP------SLSPGVSQC--FPDCVC 444

  Fly   399 QDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEW----ELYDIKTDPLERFNLA 451
            :|.|.: |:     |.:|..:..|.   |||.:..:.    |:|::..||.:..|:|
Human   445 EDAYNN-TY-----ACVRTMSALWN---LQYCEFDDQEVFVEVYNLTADPDQITNIA 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	109/492 (22%)
GNS	NP_002067.1	G6S	46..495	CDD:293766	109/494 (22%)