DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgsh and SULF1

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006716501.1	Gene:	SULF1 / 23213	HGNCID:	20391	Length:	1122	Species:	Homo sapiens

Alignment Length:	519	Identity:	113/519 - (21%)
Similarity:	191/519 - (36%)	Gaps:	159/519 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NVLLLLADDAGFESGA--YLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSS 84
            |::|:|.||...|.|:  .:||     ....:...|..|.|||.:...|.||||.:|||:..|:.
Human    44 NIILVLTDDQDVELGSLQVMNK-----TRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNH 103

  Fly    85 GMY------------GLHQ----GVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNF 133
            .:|            .:|:    .|:..|....|......:.:.:|..|..|  .::.:|...|.
Human   104 NVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPG--WREWLGLIKNS 166

  Fly   134 RFDFEQT------EEQHSINQIGRNITRMKEYARQ-FLKQAKDEKKPFFLMVGFHDPHR-----C 186
            || :..|      :|:|..           :||:. |.....:|...:|.|.....|||     .
Human   167 RF-YNYTVCRNGIKEKHGF-----------DYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVI 219

  Fly   187 GHITPQFGEFCERWGSGEEGMGSIPDWKPIY----------YDWR-NLD-----------VPAWL 229
            .|..|.          |.|  .|.|.:..:|          |::. |:|           :|..:
Human   220 SHAAPH----------GPE--DSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHM 272

  Fly   230 PDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP-----PFPGGRTNLY 289
            ..|::::::   :..|:..:|..|..:...|...|..:.|.:|||:|:|.     ....|::..|
Human   273 EFTNILQRK---RLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPY 334

  Fly   290 EHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQIPRPNDTKIVGRSILPVLREEPPI 354
            :..||.|..|..|:.|.  ......:|..:|:.|:::|...:..|.|  :.|:|:|.:|..|.|
Human   335 DFDIRVPFFIRGPSVEP--GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLDPEKP- 394

  Fly   355 KESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPIDQDFYTSPTFQQILNATLRKQT 419
                   |:            |...|::.|:      |.|           ||.......|||:.
Human   395 -------GN------------RFRTNKKAKI------WRD-----------TFLVERGKFLRKKE 423

  Fly   420 LPWYRSLLQYYQRPEWELYDIKTDPLERFNLADKAKYNGTLKQLREQLFDWQVATKDP---WRC 480
             ...:::.|....|::|  .:|       .|..:|:|              |.|.:.|   |:|
Human   424 -ESSKNIQQSNHLPKYE--RVK-------ELCQQARY--------------QTACEQPGQKWQC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	110/510 (22%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	108/505 (21%)
SULF1	XP_006716501.1	AslA	42..>386	CDD:225661	86/379 (23%)
		G6S	42..384	CDD:293766	85/377 (23%)
		DUF3740	541..676	CDD:289325
		ALP_like	<768..817	CDD:304875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810