DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgsh and Sulf1

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_008761708.1	Gene:	Sulf1 / 171396	RGDID:	708554	Length:	1117	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	115/519 - (22%)
Similarity:	191/519 - (36%)	Gaps:	159/519 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NVLLLLADDAGFESGA--YLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSS 84
            |::|:|.||...|.|:  .:||     ....:...|..|.|||.:...|.||||.:|||:..|:.
  Rat    44 NIILVLTDDQDVELGSLQVMNK-----TRKIMEHGGATFTNAFVTTPMCCPSRSSMLTGKYVHNH 103

  Fly    85 GMY------------GLHQ----GVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNF 133
            .:|            .||:    .|:..|....|......:.:.:|..|..|  .::.:|...|.
  Rat   104 NVYTNNENCSSPSWQALHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPG--WREWLGLIKNS 166

  Fly   134 RFDFEQT------EEQHSINQIGRNITRMKEYARQ-FLKQAKDEKKPFFLMVGFHDPHR-----C 186
            || :..|      :|:|..           :||:. |.....:|...:|.|.....|||     .
  Rat   167 RF-YNYTVCRNGIKEKHGF-----------DYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVI 219

  Fly   187 GHITPQFGEFCERWGSGEEGMGSIPDWKPIY----------YDWR-NLD-----------VPAWL 229
            .|..|.          |.|  .|.|.:..:|          |::. |:|           :|..:
  Rat   220 SHAAPH----------GPE--DSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHM 272

  Fly   230 PDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGP-----PFPGGRTNLY 289
            ..|:|::::   :..|:..:|..|..:...|...|....|.:|||:|:|.     ....|::..|
  Rat   273 EFTNVLQRK---RLQTLMSVDDSVERLYNMLVETGELGNTYIIYTADHGYHIGQFGLVKGKSMPY 334

  Fly   290 EHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDALQIPRPNDTKIVGRSILPVLREEPPI 354
            :..||.|..|..|:.|.  ......:|..:|:.|:::|...:..|:|  :.|:|:|.:|..|.|
  Rat   335 DFDIRVPFFIRGPSIEP--GSIVPQIVLNIDLAPTILDIAGLDTPSD--VDGKSVLKLLDLEKP- 394

  Fly   355 KESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPIDQDFYTSPTFQQILNATLRKQT 419
                   |:            |...|::.|:      |.|           ||.......|||:.
  Rat   395 -------GN------------RFRTNKKAKI------WRD-----------TFLVERGKFLRKKE 423

  Fly   420 LPWYRSLLQYYQRPEWELYDIKTDPLERFNLADKAKYNGTLKQLREQLFDWQVATKDP---WRC 480
             ...:::.|....|::|  .:|       .|..:|:|              |.|.:.|   |:|
  Rat   424 -ESSKNIQQSNHLPKYE--RVK-------ELCQQARY--------------QTACEQPGQNWQC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	112/510 (22%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	110/505 (22%)
Sulf1	XP_008761708.1	G6S	42..384	CDD:293766	87/377 (23%)
		DUF3740	534..675	CDD:403667
		ALP_like	<767..816	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810