DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and Ids

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006527908.1	Gene:	Ids / 15931	MGIID:	96417	Length:	595	Species:	Mus musculus

Alignment Length:	610	Identity:	127/610 - (20%)
Similarity:	219/610 - (35%)	Gaps:	222/610 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHSSGM 86
            |:||::.||.....|.|.:|..::||:|.||...:||.|||...:.|:|||...|||:...::.:
Mouse    40 NILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSVLFQNAFAQQAVCAPSRVSFLTGRRPDTTRL 104

  Fly    87 YG------LHQGVHNFNVLP----DTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFRFDFEQT- 140
            |.      :|.|  ||:.:|    :.|.:     ..|.|::.       |.|.::|...|:..:
Mouse   105 YDFNSYWRVHSG--NFSTIPQYFKENGYV-----TMSVGKVF-------HPGISSNHSDDYPYSW 155

  Fly   141 --EEQHSINQIGRNITRMK------------------------------EYARQFLKQAKDEKKP 173
              ...|..::...|....|                              |.|.:.|::.|....|
Mouse   156 SFPPYHPSSEKYENTKTCKGQDGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASP 220

  Fly   174 FFLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPD------WKPIYYD-WR---------- 221
            |||.||:|.||.......:|.:....     |.:...||      ..|:.|: |.
Mouse   221 FFLAVGYHKPHIPFRYPKEFQKLYPL-----ENITLAPDPHVPDSLPPVAYNPWMDIREREDVQA 280

  Fly   222 -NLDVP---------------------------AW------------LPDTDVV-----RQELAA 241
             |:.||                           :|            || ::|:     |:...:
Mouse   281 LNISVPYGPIPEDFQHRCSICSILILRQSSCESSWKEHLLLLSRGFQLP-SEVLCLFAERKIRQS 344

  Fly   242 QYMTISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGPPFPGGRTNLYEHG-----------IRS 295
            .:.::|.||..||.:|..|:...:|..|::.:|||:|       ..|.|||           .|.
Mouse   345 YFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHG-------WALGEHGEWAKYSNFDVATRV 402

  Fly   296 PLIISSPNK--------------------------EDRHHEATAAMVSLLDIYPSVMDALQIPRP 334
            ||::..|.:                          ..||   |..:|.|:.::|::.....:|.|
Mouse   403 PLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRH---TEDLVELVSLFPTLAGLAGLPVP 464

  Fly   335 NDTKI---------VGRSI-----LPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKL 385
            ....|         .|:::     |..|.|||      .:||:          |..::...:|..
Mouse   465 PRCPIPSFHVELCREGQNLQKHLQLHDLEEEP------DLFGN----------PRELIAYSQYPR 513

  Fly   386 IHNINYW-ADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEW----------ELYD 439
            ..:...| :|.|...|.       :::..::|  |:.:..::...:...|:          |||.
Mouse   514 PADFPQWNSDKPSLNDI-------KVMGYSIR--TVDYRYTVWVGFDPSEFLANFSDIHAGELYF 569

  Fly   440 IKTDPLERFNLADKAKYNGTLKQLR 464
            :.:|||:..|:.:.:::.|.|..||
Mouse   570 VDSDPLQDHNVYNDSQHGGLLHSLR 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	127/610 (21%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	127/610 (21%)
Ids	XP_006527908.1	iduronate-2-sulfatase	40..586	CDD:293754	123/600 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810