DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and arsk

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_017946283.2	Gene:	arsk / 100485065	XenbaseID:	XB-GENE-1000369	Length:	536	Species:	Xenopus tropicalis

Alignment Length:	553	Identity:	122/553 - (22%)
Similarity:	205/553 - (37%)	Gaps:	158/553 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NVLLLLADDAGFESGAYL---NKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAGHS 83
            ||:::::|  .|:....|   ......|.::.:.:.|.||.||:|:...|.|||:.:.:|...|
Frog    35 NVVMVMSD--AFDGRLTLLPEKSLVSLPYINFMKQHGALFLNAYTNSPICCPSRAAMWSGLFPH- 96

  Fly    84 SGMYGLHQGVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFRFDFEQTEEQHSIN- 147
                 |.:..:|:..|  ....|..:........::..:||:            :.|...||::
Frog    97 -----LTESWNNYKCL--NSEYPTWMDKVEKNGYVTQRLGKQ------------DYTSGSHSLSN 142

  Fly   148 --------------QIGR---NITRMKEYARQFL--------------KQAKDEKKPFFLMVGFH 181
                          |.||   |:|..|...|...              |.|::..:||||.:|.:
Frog   143 RVEAWTRDVPFLLRQEGRPCANLTGNKTQTRVMTQDWKNADTAAGWIQKAAQNSSQPFFLYLGLN 207

  Fly   182 DPHRCGHITPQFGE-FCERWGSGEEGMGS------------IPDWKPI-------YYDWRNLDVP 226
            .||      |...| ..|.:||......|            :|:|||:       ||.....:..
Frog   208 LPH------PYPSENMGENFGSSTFLTSSYWLQKVSYKNVTVPEWKPLQSMHPVDYYSSYTKNCT 266

  Fly   227 AWLPDTDVVRQELAAQYMTI-SRLDQGVGLMLKELEAAGVADQTLVIYTSDNGPPFPGGR----T 286
            |  |.||...:::.|.|..: :..|..:|.::..|...|:..:|.|::|||:|......|    .
Frog   267 A--PFTDQEIRDIRANYYAMCAEADGLLGEIISALNDTGLLSRTYVVFTSDHGELAMEHRQFYKM 329

  Fly   287 NLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMD--ALQIPRPNDTKIVGRSILPVL- 348
            ::||.....||:|..|........:|  :|||:|:||::::  .:|||:    .|.|.|::|:|
Frog   330 SMYEGSSHVPLLIMGPGISPGQQIST--IVSLVDLYPTMLEIAGVQIPQ----NISGFSLMPLLS 388

  Fly   349 -REEPPIKESDSVFGSH------SYHEVTMAYPMRMVRNRRYKLIHNINYW-------ADFPIDQ 399
             |.|   |...|...:|      .:|.........|:|:         |||       .|..|.|
Frog   389 ARSE---KNVPSCTNAHPNWALSEFHGSDANASTYMLRD---------NYWKYIAYADGDSVIPQ 441

  Fly   400 DFYTSPTFQQILNATLR-----KQTLPWYRSLLQY---------YQRPEWELYDIKTDPLERFNL 450
            .|..|....::.|...:     ::.....||::.|         |.:.::.|:.....
Frog   442 LFDLSSDPDELRNVAAQVPEKVQEMDKKLRSIIDYAKVSASVHVYNKQQFALWKASIG------- 499

  Fly   451 ADKAKYNGTLKQLREQLFDWQVATKDPWRCAPH 483
               |.|...:..||     |.    ..|...|:
Frog   500 ---ANYTNVISNLR-----WH----SDWNTRPN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	120/544 (22%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	119/539 (22%)
arsk	XP_017946283.2	ARSK	35..450	CDD:293781	109/462 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910