DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and sgsh

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001120065.1	Gene:	sgsh / 100145064	XenbaseID:	XB-GENE-1005174	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	256/506 - (50%)
Similarity:	337/506 - (66%)	Gaps:	21/506 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 W-IFTLWLIAGCSAGPQNVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCS 69
            | |::|.|::  .|..:||||::.|||||||..|.|....||||..|:||.|:|.||||||||||
Frog    11 WVIYSLLLLS--KAWGRNVLLIIGDDAGFESEVYNNTAIHTPNLRDLSKRSLIFKNAFTSVSSCS 73

  Fly    70 PSRSQLLTGQAGHSSGMYGLHQGVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKKHVGAANNFR 134
            |||:.::||...|.:|||||||.:|:||...|..|||.::| |:|  |.:|||||||:|..:.:.
Frog    74 PSRAAIMTGLPQHQNGMYGLHQDMHHFNSFDDVRSLPLILR-QAG--IRTGIIGKKHIGPESVYP 135

  Fly   135 FDFEQTEEQHSINQIGRNITRMKEYARQFLKQAKDEKKPFFLMVGFHDPHRCGHITPQFGEFCER 199
            |||..|||..|:.|:||||||:|...|:|| |::|: :||.|.|.|||||||||..||:|.|||:
Frog   136 FDFSYTEENSSVLQVGRNITRIKLLVRKFL-QSQDQ-RPFLLYVAFHDPHRCGHSQPQYGAFCEK 198

  Fly   200 WGSGEEGMGSIPDWKPIYYDWRNLDVPAWLPDTDVVRQELAAQYMTISRLDQGVGLMLKELEAAG 264
            :|:|:..||.:|||.|.||....:.||.::.||...|:::||||.||.|:|||:||:|.||..||
Frog   199 FGNGDPDMGIMPDWSPQYYTPEQVQVPYFIQDTPSARKDIAAQYTTIGRMDQGIGLVLSELYNAG 263

  Fly   265 VADQTLVIYTSDNGPPFPGGRTNLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDAL 329
            ..:.||||::||||.|||.||||||..|...||::|||..:.|..:.:.:..|||||.|:|:|..
Frog   264 HENDTLVIFSSDNGIPFPNGRTNLYWSGRAEPLLVSSPYHQKRWGQISQSFASLLDITPTVLDWF 328

  Fly   330 QIPRPN------DTKIVGRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHN 388
            .||.||      ..::.|:|:||.|:.|   ::..:||||.|:|||||.||||.|:|.:|.||||
Frog   329 SIPYPNYKIFGKSVQLTGKSLLPALQSE---QDWTTVFGSQSHHEVTMYYPMRSVQNLQYLLIHN 390

  Fly   389 INYWADFPIDQDFYTSPTFQQILNATLRKQTLPWYRSLLQYYQRPEWELYDIKTDPLERFNLADK 453
            :|:...||||||||.|||||.:||.|:..|...|:::|..||.|..|||||...|..|..|:|:.
Frog   391 LNFKMPFPIDQDFYVSPTFQDLLNRTVSGQPTSWFKTLHNYYYRDRWELYDRSADISEIKNIAED 455

  Fly   454 AKYNGTLKQLREQLFDWQVATKDPWRCAPHAVLQEQGVYKDQPVCLTLGHE 504
            ..|...||.::..|..||..|.|||.|||..||:|    |.:|.|..|.:|
Frog   456 PAYQDILKSMQNILQKWQSETSDPWMCAPDGVLEE----KLEPQCRPLYNE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	238/464 (51%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	234/454 (52%)
sgsh	NP_001120065.1	SGSH	26..473	CDD:293751	234/454 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1145
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H167
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1384
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194238at33208
OrthoFinder	1	1.000	-	-		FOG0007960
OrthoInspector	1	1.000	-	-		oto103326
Panther	1	1.100	-	-	LDO	PTHR43108
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160