DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgsh and gns

DIOPT Version :9

Sequence 1:	NP_650760.1	Gene:	Sgsh / 42266	FlyBaseID:	FBgn0038660	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001107314.1	Gene:	gns / 100135105	XenbaseID:	XB-GENE-978429	Length:	533	Species:	Xenopus tropicalis

Alignment Length:	585	Identity:	131/585 - (22%)
Similarity:	217/585 - (37%)	Gaps:	192/585 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IAGCSAGPQNVLLLLADDAGFESGAYLNKFCQTP---NLDALAKRGLLFNNAFTSVSSCSPSRSQ 74
            :.|.|..| ||:|:|.||.....|.      .||   ..:.:|..|::|:||:.:.:.|.||||.
Frog    24 VEGRSRKP-NVVLILTDDQDVSLGG------MTPLKKTKELIADHGMMFSNAYVASALCCPSRSS 81

  Fly    75 LLTGQAGHSSGMYGLHQGVHN----------FNVLPDTGSLPNLI-------------RDQSGGR 116
            :|||:..|:      |..|:|          :....:..:.|.|:             .:|.|..
Frog    82 ILTGRYPHN------HHVVNNTVEGNCSSKAWQKTQEPYTFPALLFSIGYQTFFAGKYLNQYGSE 140

  Fly   117 ILSGIIGKKHVGAANNFRFDFEQTEE--QHSINQIGRNITRMKEYARQFLKQA-----------K 168
            ...||   .||....::.|..|:..:  .:::::.||..|..:.|::.:|...           |
Frog   141 EAGGI---NHVPPGWSYWFALEKNSKYYNYTLSENGRPKTHGENYSQDYLTDVLANVSLDFLNYK 202

  Fly   169 DEKKPFFLMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNLDVPA------ 227
            ....|||:|:....||......||                         |:...|:|.|
Frog   203 SNYAPFFMMIATPAPHSPWTAAPQ-------------------------YETAFLNVSAPRGSNF 242

  Fly   228 --------WLPDTDVVRQ------ELAAQYM---------TISRLDQGVGLMLKELEAAGVADQT 269
                    ||     :||      ..:.||:         |:..:|..|..::|:|||.|..|.|
Frog   243 NVHGKDKHWL-----IRQAKSPMSNSSIQYLDNAFQKRWQTLLSVDDLVEKLVKQLEARGELDNT 302

  Fly   270 LVIYTSDNGP-----PFPGGRTNLYEHGIRSPLIISSPNKEDRHHEATAAMVSLLDIYPSVMDAL 329
            .:.:|||||.     ..|..:..|||..|:.||::..|.  .:.::.|.::|:.:|:.|:::|..
Frog   303 FIFFTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPG--IKPNQITKSLVANIDLGPTILDIA 365

  Fly   330 QIPRPNDTKIVGRSILPVLREEPPIKESDSVFGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWAD 394
            .... |.|::.|.|.|||                             |:.|      .|:|:..|
Frog   366 GYDL-NKTQMDGMSFLPV-----------------------------MINN------SNVNWRTD 394

  Fly   395 FPID---QDFYTS-PT-----------FQQILNATLRKQTLPWYRSL-----LQYYQRPE----W 435
            ..::   :...|| ||           |...:.......|....|::     |||.:..:    .
Frog   395 ILVEYQGEGSNTSDPTCPALGPGVSQCFPDCVCEDSYNNTYACVRTIAAAYDLQYCEFDDAEVFA 459

  Fly   436 ELYDIKTDPLERFNLADKAKYNGTLKQLREQLFDWQVATK---------DP-WRCAPHAVLQEQG 490
            |:|:|..||.:..|:| |......|:::..:|...|..:.         || :|..|..:..|||
Frog   460 EVYNITADPNQLTNIA-KTIDQEILEKMNHRLMMLQSCSGPSCHTPGVFDPRYRFDPRLMFTEQG 523

Fly 491 490
Frog 524 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	123/564 (22%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	120/545 (22%)
gns	NP_001107314.1	G6S	30..478	CDD:293766	119/532 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000