DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and Sh3gl3

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_006229542.1	Gene:	Sh3gl3 / 81921	RGDID:	620578	Length:	347	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	185/370 - (50%)
Similarity:	247/370 - (66%)	Gaps:	28/370 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||.:||:|..:||:.||||||||.:|::||:|.|:|.:.|.|:..|..|:|||||..|
  Rat     1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLDMEKKIDITSKAVAEILSKATEYLQPNPAYR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||:..:..:|||.||.|:..|||.||||.:|||.||::|||| |.|..:|||.|||||.||:||.
  Rat    66 AKLGMLNTMSKLRGQVKATGYPQTEGLLGDCMLKYGRELGED-SAFGNSLVEVGEALKLMAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||.|:||.|::||..:|.|||||:.||.:||:|||||:|.|::|..|  ::|||.|.:||.||.
  Rat   130 SLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKKRVGKIPEEEIRQAVEKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            :||:..|||.||||.|.||||..|.||..|:|.|..::|:.||..|:.:.:.|...||.:::||.
  Rat   195 ELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQNKLELRIALASQVPRRDYMPKP 259

  Fly   259 LLDLNLDGGGGGLNEDGTPSHISS--SASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENP 321
            :       .....|.:|.....||  :.:.:||                .||||:.||||||||.
  Rat   260 V-------NTSSTNANGVEPSSSSKLTGTDIPS----------------DQPCCRGLYDFEPENE 301

  Fly   322 GELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
            |||.|||.|||||.|::|:||:||.:.|.:|:||.:||:|.||||
  Rat   302 GELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPLP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	120/222 (54%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	31/48 (65%)
Sh3gl3	XP_006229542.1	BAR_Endophilin_A3	25..247	CDD:153299	120/222 (54%)
Sh3gl3	XP_006229542.1	SH3_Endophilin_A	288..342	CDD:212737	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339825
Domainoid	1	1.000	258	1.000	Domainoid score	I1931
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37723
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2126
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm46336
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770