DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EndoA and STAM

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_003464.1	Gene:	STAM / 8027	HGNCID:	11357	Length:	540	Species:	Homo sapiens

Alignment Length:	279	Identity:	59/279 - (21%)
Similarity:	115/279 - (41%)	Gaps:	53/279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KSNTYPQPEGLLAECMLTYGKKLG-EDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLH 145
            :|.|.|:      :|:.:..:::. :|..|..|||...|..:.....:.:.  :...::|...:.
Human    38 QSRTGPK------DCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHL--EVCSRDFASEVS 94

  Fly   146 HMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFGESLQLAQVGMFNLLENDTEH 210
            ::..|...:|.   :||:...:::                .|:|....||:.:..  :::|..|
Human    95 NVLNKGHPKVC---EKLKALMVEW----------------TDEFKNDPQLSLISA--MIKNLKE- 137

  Fly   211 VSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDG 275
              |.|||..    ..||.|:..:.....:.:......::...|.:.|. ::|:|.
Human   138 --QGVTFPA----IGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKA-IELSLK---------- 185

  Fly   276 TPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDD 340
            .....|::.|.|     .|:.|..:|..:.:....:|:||||.....||.||..:|||:|:..|.
Human   186 EQRQQSTTLSTL-----YPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDP 245

  Fly   341 NWFEGAVNGRTGYFPQSYV 359
            ||::|..:...|.||.::|
Human   246 NWWKGETHQGIGLFPSNFV 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	28/164 (17%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	21/48 (44%)
STAM	NP_003464.1	VHS_STAM	9..142	CDD:239625	23/135 (17%)
		SH3_STAM1	213..267	CDD:212897	21/52 (40%)
		GAT	306..377	CDD:281166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030