DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and SH3GL3

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001311111.1	Gene:	SH3GL3 / 6457	HGNCID:	10832	Length:	360	Species:	Homo sapiens

Alignment Length:	299	Identity:	152/299 - (50%)
Similarity:	201/299 - (67%)	Gaps:	14/299 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||.:||:|..:||:.||||||||.:|::||||.|||.::|.|:..||.|:|||||..|
Human     1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||:..:..:||:.||.|:..|||.||||.:|||.|||:|||| |.|..||:|.||::|.||:||.
Human    66 AKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGED-STFGNALIEVGESMKLMAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||.|:||.|::||..:|.|||||:.||.|||:|||||:|.|::|..|  |:|:|.|.:||.||.
Human   130 SLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            :||:..|||.||||.|.||||..|.||..|:|.|..::|:.||..||.:.|.|.|.||.|:.|:.
Human   195 ELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRP 259

  Fly   259 LLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKS 297
                 :......||...|.|.:.::.      :||..||
Human   260 -----VKRSSSELNGVSTTSVVKTTG------LRSKRKS 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	124/222 (56%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737
SH3GL3	NP_001311111.1	Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21		11/19 (58%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87		11/26 (42%)
		Interaction with ARC. /evidence=ECO:0000250	218..254		16/35 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..271		7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146068
Domainoid	1	1.000	265	1.000	Domainoid score	I1904
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37723
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2150
Isobase	1	0.950	-	0	Normalized mean entropy	S1658
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm42187
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750