DRSC/TRiP Functional Genomics Resources

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Protein Alignment EndoA and SH3GL1

DIOPT Version :10

Sequence 1:NP_620122.2 Gene:EndoA / 42265 FlyBaseID:FBgn0038659 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_003016.1 Gene:SH3GL1 / 6455 HGNCID:10830 Length:368 Species:Homo sapiens


Alignment Length:372 Identity:187/372 - (50%)
Similarity:256/372 - (68%) Gaps:11/372 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||..||:|.::||:|||||||||.||.|||:|.|||.:.|.|:..:|.|:|||||.:|
Human     1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||:..:..:||:.||.|:..|||.||||.|||:.:||:||.::: |..||::.||::|::|:||.
Human    66 AKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESN-FGDALLDAGESMKRLAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||..:||||::||.::..|||||:.||.|||:|||||||.|::||.|  |:|:|.|.:||.||.
Human   130 SLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            ::|:..|.||||.|.|.||||....:|..|:|.|...:|..|.|.|:.:..||.|||:.|:.||.
Human   195 EVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKP 259

  Fly   259 LLDLNL---DGGGGGLNEDGTPS-HISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPE 319
            ....:|   :...||......|. ..|||......|:|:|::||...    .||.|:||||||||
Human   260 REPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPL----DQPSCKALYDFEPE 320

  Fly   320 NPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
            |.|||.|.|.|:|||.|::|:||:||.::|::|:||.|||:|.||||
Human   321 NDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLP 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EndoANP_620122.2 BAR_Endophilin_A 25..246 CDD:153276 113/222 (51%)
SH3_Endophilin_A 312..361 CDD:212737 31/48 (65%)
SH3GL1NP_003016.1 Membrane-binding amphipathic helix. /evidence=ECO:0000250 1..21 11/19 (58%)
BAR_Endophilin_A 25..247 CDD:153276 113/222 (51%)
Required for dimerization upon membrane association. /evidence=ECO:0000250 60..87 11/26 (42%)
Interaction with ARC. /evidence=ECO:0000250 218..254 13/35 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..308 20/67 (30%)
SH3_Endophilin_A 309..363 CDD:212737 33/53 (62%)

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