DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and sh3gl3a

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001075160.1	Gene:	sh3gl3a / 571626	ZFINID:	ZDB-GENE-070112-242	Length:	352	Species:	Danio rerio

Alignment Length:	373	Identity:	194/373 - (52%)
Similarity:	258/373 - (69%)	Gaps:	29/373 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||.|||::||:|.::||:.||||||||.||||||||.:||.:.|.||..||.|:|||||.:|
Zfish     1 MSVAGFKKQLHKASQLLSEKISGAEGTKLDEDFMEMERKIEVTNKSVFELITKTTEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||:..:..:||:.||.|:..|||.||||.:|||.||::|||: |.|..||.:.|||:|||||:|.
Zfish    66 AKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLRYGRELGEE-SAFGTALADIGEAMKQMADIKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            :||.::||||::||.::|.|||||::||.|||:|||||||.|::||.|  |:||:.|.:||.||.
Zfish   130 ALDISVKQNFIDPLQNLQDKDLKEIVHHLKKLEGRRLDFDYKKKRQGKIPDEEIKQAVEKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            :||:..|||.||||.|.||||....||..::|.|..::|:.|...||.:.|.|..||:.||.||:
Zfish   195 ELAERSMFNFLENDVEQVSQLSALIEAALEYHRQSLEILKDLDSKLQNRISTASRRPKKEFKPKS 259

  Fly   259 LLDLNLDG----GGGGLNEDGTPSHISS-SASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEP 318
            ::. :|:.    ...||      ||.|| .::.|.|.|              .||||::||||||
Zfish   260 IVS-SLESVENTQHNGL------SHTSSIKSTELESHM--------------DQPCCRSLYDFEP 303

  Fly   319 ENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
            ||.|||.|||.|||.|.|::|:||:||.:||.:|:||.:||.|.||||
Zfish   304 ENEGELGFKEGDIIILTNQIDENWYEGMINGESGFFPINYVDVLVPLP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	124/222 (56%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	31/48 (65%)
sh3gl3a	NP_001075160.1	BAR_Endophilin_A3	25..247	CDD:153299	124/222 (56%)
sh3gl3a	NP_001075160.1	SH3_Endophilin_A	293..347	CDD:212737	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579590
Domainoid	1	1.000	243	1.000	Domainoid score	I2161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37723
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2238
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm25526
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910