Protein Alignment EndoA and grb2

DIOPT Version :9

• Sequence 1: NP_001262717.1
• Gene: EndoA / 42265
• FlyBaseID: FBgn0038659
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_001008130.1
• Gene: grb2 / 493492
• XenbaseID: XB-GENE-6070000
• Length: 229
• Species: Xenopus tropicalis
• Alignment Length: 227
• Identity: 52/227 - (22%)
• Similarity: 79/227 - (34%)
• Gaps: 92/227 - (40%)

  Fly   218 AEALYDFHSQC--------ADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLN----------- 263
            |.|.|||.:..        .|:|:.|.|...:...:||...::.|:||..:::.
 Frog     3 AVAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPR 67

  Fly   264 --------------------------------------------LDGGG---------GGLNEDG 275
                                                        .||.|         ..||| .
 Frog    68 AKAEEMLGKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNE-L 131

  Fly   276 TPSHISSSASPLPSPMRSP---AKSMAVTPQ----------RQQQPCCQALYDFEPENPGELAFK 327
            ...|.|:|.|      |:.   .:.:...||          .||....|||:||:|:..|||.|:
 Frog   132 VDYHRSTSVS------RNQQIFLRDIEQVPQVHGGDRATNLLQQPTYVQALFDFDPQEDGELGFR 190

  Fly   328 ENDIITLLNRVDDNWFEGAVNGRTGYFPQSYV 359
            ..|.|.:::..|.||::|...|:||.||::||
 Frog   191 RGDFIQVVDNSDPNWWKGTCLGQTGMFPRNYV 222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	9/35 (26%)
		SH3_Endophilin_A	312..361	CDD:212737	22/48 (46%)
grb2	NP_001008130.1	SH3_GRB2_N	1..56	CDD:212879	14/52 (27%)
		SH2_Grb2_like	56..150	CDD:199828	11/100 (11%)
		SH3_GRB2_C	172..224	CDD:212882	23/51 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030