DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and stam2

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001007370.2	Gene:	stam2 / 492497	ZFINID:	ZDB-GENE-041114-64	Length:	509	Species:	Danio rerio

Alignment Length:	171	Identity:	43/171 - (25%)
Similarity:	68/171 - (39%)	Gaps:	35/171 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 DFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDG----TPSHISSS 283
            :|.|:...||......:.||.....:....:|.....|.| :......|.|:|    |.:..|||
Zfish    88 EFASEVRGVLNRAHPKVNEKLKALMAEWAEDFQKDPQLSL-IGATIKSLKEEGVTFPTANPQSSS 151

  Fly   284 ASPLPSPMRSP-------AKSMAVTPQRQQQPC-----------------------CQALYDFEP 318
            ..|..:|..|.       ||::.::.|.|:|..                       .:||||||.
Zfish   152 TKPSSTPATSRASADDDLAKAIELSLQEQKQQTETRPLTVIADPPYNTNGGKESRKVRALYDFEA 216

  Fly   319 ENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYV 359
            ....||.||..:::.:|:..|.||::|..:...|.||.::|
Zfish   217 AEDNELTFKAGELVIILDDSDPNWWKGENHRGVGLFPSNFV 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	6/22 (27%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	19/48 (40%)
stam2	NP_001007370.2	VHS_STAM	9..147	CDD:239625	13/59 (22%)
		SH3_STAM	206..259	CDD:212754	19/52 (37%)
		GAT	295..368	CDD:281166
		Forkhead_N	366..479	CDD:254796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030