DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and sh3gl3b

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_956475.2	Gene:	sh3gl3b / 393150	ZFINID:	ZDB-GENE-040121-4	Length:	386	Species:	Danio rerio

Alignment Length:	386	Identity:	166/386 - (43%)
Similarity:	244/386 - (63%)	Gaps:	21/386 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||.|||.:||:|.:.||:.|.||||||.:|:.|||||::|.:|:.::..||..:|||||..|
Zfish     1 MSVAGFKKQFHKASQLLKEKINGVEGTKLDEEFLSMERKTEITHKLILDIVPKTIGYLQPNPAYR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||::.:..:|::.|..|:..|||.||:|.:|||.||.:||.: |.|..||:|.||||||:|..:.
Zfish    66 AKLSMLSTVSRIRGHVKAVGYPQTEGILGDCMLQYGSELGAE-SGFGFALLEMGEALKQVAQARD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            .:|..:|:.|::||..:|.|:|||:..|.:||:|||||||.|:||:.|  |.||:.|.|||.||.
Zfish   130 CMDVRVKRAFIDPLQSLQQKELKEIGFHLRKLEGRRLDFDYKKRRKGKIADSEIKKAFDKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPK- 257
            ::|:..||||||.|.:.:..|....||:.|:|.|.:.:|..|:..||.|..:|.::|:.||..|
Zfish   195 EMAERCMFNLLEKDVQRMQHLSGLLEAVIDYHRQSSQILENLRSNLQTKIRDASNKPKREFASKS 259

  Fly   258 ---TLLDLNLDGGGGGLNEDGTPSHISSSASPLPSP--MRSPAKSMAVTPQRQQ----------- 306
               |:...::.|.....:...:.:.|:.:.|...:|  :..|.:....||...:
Zfish   260 VASTVCYSDIYGFSTCSSGPSSDTEITEALSEKYAPVVVHRPEQVTIKTPTTDKPASINDRAPPL 324

  Fly   307 -QPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
             ||||||||.|:.||.|||.|||.|||.|.:::|:||:||.:.|::|.||.:||:|.||||
Zfish   325 DQPCCQALYSFQAENQGELGFKEGDIIILTSQIDENWYEGMIRGQSGLFPMNYVKVLVPLP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	104/222 (47%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	27/48 (56%)
sh3gl3b	NP_956475.2	BAR_Endophilin_A	25..247	CDD:153276	104/222 (47%)
sh3gl3b	NP_956475.2	SH3_Endophilin_A	327..381	CDD:212737	31/53 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579591
Domainoid	1	1.000	243	1.000	Domainoid score	I2161
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2238
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm25526
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800