DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and stam

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_005163512.1	Gene:	stam / 386967	ZFINID:	ZDB-GENE-031118-123	Length:	516	Species:	Danio rerio

Alignment Length:	279	Identity:	62/279 - (22%)
Similarity:	110/279 - (39%)	Gaps:	51/279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KSNTYPQPEGLLAECMLTYGKKLG-EDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLH 145
            :|.|.|:      ||:.:..:::. :|..|..|||...|..:.....:.:.  :...:.|...:.
Zfish    38 QSRTGPK------ECLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHL--EVCSREFASEVS 94

  Fly   146 HMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFGESLQLAQVGMFNLLENDTEH 210
            ::..|...:|....|.|.                  :..||| |....||:.:..  :::|..|
Zfish    95 NVLNKGHPKVCEKLKALM------------------VEWAED-FRNDPQLSLISA--MIKNLRE- 137

  Fly   211 VSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDG 275
              |.|.|...    .||.|:..:.....:.:..:.:.::...|.:.|. ::|:|        :|.
Zfish   138 --QGVIFPAV----GSQAAEQAKASPALVAKDPATSTNKKEEEDLAKA-IELSL--------KDQ 187

  Fly   276 TPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDD 340
            .......|.|.|     .|:.|..:|..:......:|:||||.....||.||..:|||:|:..|.
Zfish   188 RHQQPQVSLSGL-----YPSTSSLLTSHKTDGRKVRAIYDFEAAEDNELTFKSGEIITILDDSDP 247

  Fly   341 NWFEGAVNGRTGYFPQSYV 359
            ||::|......|.||.::|
Zfish   248 NWWKGETYQGVGLFPSNFV 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	30/164 (18%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	21/48 (44%)
stam	XP_005163512.1	VHS_STAM	9..142	CDD:239625	26/135 (19%)
		SH3_STAM1	215..269	CDD:212897	21/52 (40%)
		GAT	306..379	CDD:281166
		WWbp	<393..482	CDD:304964
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030