DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and sh3gl1b

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_021333879.1	Gene:	sh3gl1b / 378838	ZFINID:	ZDB-GENE-031001-6	Length:	367	Species:	Danio rerio

Alignment Length:	379	Identity:	185/379 - (48%)
Similarity:	265/379 - (69%)	Gaps:	24/379 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||..||:|.::||:|||||||||.:|.::|||.|||.:.|.|:..||.|:|||||.:|
Zfish     1 MSVAGLKKQFYKASQMVSEKVGGAEGTKLDEEFKDLERKVDVTNKAVVEVISKTSEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||::.:..:||:.||.||..|||.||||.|||..||::|||:.: |..||:|.||::|::|:||.
Zfish    66 AKLSMLNTMSKIRGQVKSPGYPQAEGLLGECMGKYGRELGEETN-FGGALMEVGESMKRLAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||.::||||::||..:..|||:|:.||.|||:|||||:|.|::||.|  |:|:|.|.:||.||.
Zfish   130 SLDIDVKQNFIDPLQGLCDKDLREIQHHLKKLEGRRLDYDYKKKRQGKIPDEELRQALEKFHESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFV--P 256
            ::|::.|:||||.|.|.||||.:..|:...:|.|...:|..|.:.|:::..:|::|||.|::  |
Zfish   195 EVAEISMYNLLETDIEQVSQLSSLVESQLQYHRQAVQILDELSDKLRDRMKDAQTRPRKEYIPKP 259

  Fly   257 KTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSM----AVTPQR----QQQPCCQAL 313
            |.::|.      |..||.....:..|||    .|||: |:|.    .:|.::    .:|.||:||
Zfish   260 KPVIDF------GETNEQSNGGYTPSSA----PPMRN-AESYHQFGRITTRKPRLPAEQACCKAL 313

  Fly   314 YDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLPN 367
            |||||||.|||.|.|.|||||.|::|:||:||.:.|::|:||.:||:|.||||:
Zfish   314 YDFEPENEGELGFHEGDIITLTNQIDENWYEGMLRGQSGFFPLNYVEVIVPLPH 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	111/222 (50%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	31/48 (65%)
sh3gl1b	XP_021333879.1	BAR_Endophilin_A	25..247	CDD:153276	111/222 (50%)
sh3gl1b	XP_021333879.1	SH3_Endophilin_A	309..362	CDD:212737	33/52 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2161
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2238
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm25526
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870