DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and Dlish

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_611251.2	Gene:	Dlish / 37014	FlyBaseID:	FBgn0034264	Length:	355	Species:	Drosophila melanogaster

Alignment Length:	225	Identity:	53/225 - (23%)
Similarity:	86/225 - (38%)	Gaps:	51/225 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 HMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFGESLQLAQVGMFNLL--ENDT 208
            |..:.|.|.|:.|         ||     ....|||:   |.|.|:        :.|:|  |||.
  Fly    54 HGLSPDSKMVVLH---------DF-----TPCVDDEL---EVKRGQ--------LVNILYRENDW 93

  Fly   209 EHVSQLVTFAEALYDFHSQCADVLRGLQETLQEK---RSEAESRPRNEFVPKTLLDLNLDGGGGG 270
            .:|....:..|....| |.||.....|.:...:|   |.:...:|..|.:|....|..||
  Fly    94 VYVIGQDSRQEGFIPF-SYCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLD----- 152

  Fly   271 LNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQ-----RQQQPCCQALYDFEPENPGELAFKEND 330
                     :....:..|....|...::.|.|:     ::....|..||.|...:..:|:.:..:
  Fly   153 ---------VLCDETLNPGSANSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGE 208

  Fly   331 IITLLNRVDDNWF-EGAVNGRTGYFPQSYV 359
            .:|:|||.|.:|| ....:|:.|:.|.|::
  Fly   209 FVTVLNREDPDWFWIMRSDGQEGFVPASFI 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	27/104 (26%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	15/49 (31%)
Dlish	NP_611251.2	SH3	61..111	CDD:212690	19/75 (25%)
		SH3	184..238	CDD:214620	16/53 (30%)
		SH3	293..346	CDD:212690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840