DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and POSH

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster

Alignment Length:	186	Identity:	51/186 - (27%)
Similarity:	81/186 - (43%)	Gaps:	35/186 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 VSQLVTFAEALYDFHSQCADVLRGLQETLQEKR---------SEAESRPRNEFVPKTLLDLNLDG 266
            :.:|.|.::.|...|:.|...|:.:..:..:.|         .:.:..|.|..:.:.|..:..:.
  Fly    16 LERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPPNVLLMRILEGMKQNA 80

  Fly   267 GGGGLNEDGTPSHIS-SSASPLPSPMRSPAKSMAV---------------TPQRQQQ-----PCC 310
            ..|...|.|..:... ..|.|.|     ||:|:|.               .|.|.:|     |..
  Fly    81 AAGKGEEKGEETETQPERAKPQP-----PAESVAPPDNQLLQLQSHQQSHQPARHKQRRFLLPHA 140

  Fly   311 QALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
            .||:||......:|.||:.|:|.:.:|:|:|||.|..||:.|.||.:||:|.||||
  Fly   141 YALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSVPLP 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	7/43 (16%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	22/48 (46%)
POSH	NP_523776.1	RING	11..53	CDD:238093	7/36 (19%)
		SH3	139..191	CDD:302595	22/51 (43%)
		SH3_SH3RF_2	199..251	CDD:212721
		SH3_SH3RF_3	424..477	CDD:212717
		SH3_SH3RF_C	782..836	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030