DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and CAP

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	67/262 - (25%)
Similarity:	113/262 - (43%)	Gaps:	66/262 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DVKYSLD----DNIKQNFLEPLHHMQTKDLKE------VMHHRKKLQGRRLDFDCKRRR----QA 177
            |..||.|    .::..:|..|:.|.|.::|.|      ...|.:||      :..:|||    :.
  Fly  2214 DFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKL------YHEERRRKYLQEL 2272

  Fly   178 KDDEIRGAEDKFGESLQLAQVGMFNLLENDTE-HVSQLV---TFAEALYDFHSQCADVL---RGL 235
            :|...|...|.|..| |.:.:.:....:..|: .:..||   |.|.||::|..|.:..|   :|
  Fly  2273 QDMNSRRHTDNFTPS-QKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKG- 2335

  Fly   236 QETLQEKRS------EAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSP 294
             :|:..:|.      |.|.......:|.:.:::        ::.||.               |:|
  Fly  2336 -DTIYIRRQIDANWYEGEHNAMIGLLPASYVEI--------VSRDGA---------------RTP 2376

  Fly   295 AKSMAVTPQRQQQPCCQALYDFEPENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYV 359
            :|       |..:...:|.|:|:.::..||:..:.:::||..|||.|||||.:..|.|.||.|||
  Fly  2377 SK-------RPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYV 2434

  Fly   360 QV 361
            :|
  Fly  2435 EV 2436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	35/145 (24%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	22/48 (46%)
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404
		SH3_Sorbs_1	2315..2367	CDD:212715	12/53 (23%)
		SH3_Sorbs_2	2384..2436	CDD:212716	22/51 (43%)
		SH3_Sorbs_3	2514..2567	CDD:212714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010