DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and Stam

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_477448.1	Gene:	Stam / 34505	FlyBaseID:	FBgn0027363	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	72/295 - (24%)
Similarity:	117/295 - (39%)	Gaps:	61/295 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KSNTYPQPEGLLAECMLTYGKKLGE-DNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLH 145
            |..|.|:   |..:|:....:::|. |..|..||:               :|.|.:..|..:|||
  Fly    36 KVTTNPR---LAKDCLKAVMRRMGHTDPHVVMQAI---------------TLLDALSNNCGKPLH 82

  Fly   146 HMQTKDLKEVMHHRKKLQGRRLDFDCK-RRRQAKDDEIRGAEDKFGESLQLAQVGMFNLLENDTE 209
                            |:....||:.: ||..||      |:.|.  ||::.|| :.|..|||.:
  Fly    83 ----------------LEVASRDFETEFRRLLAK------AQPKV--SLKMRQV-LKNWAENDYK 122

  Fly   210 HVSQL-------VTFAEALYDFHSQCADVLRGLQE---TLQEKRSEAESRPRNEFVPKTLLDLNL 264
            :..:|       ....:..|||.:......:.:.|   .|.:..:...|:...:.:.|. ::|:|
  Fly   123 NDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDDIAKA-IELSL 186

  Fly   265 DGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPC-----CQALYDFEPENPGEL 324
            ....|........|..::||.|...|..:...|.|.:.:....|.     .:||||||.....||
  Fly   187 KENKGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENEL 251

  Fly   325 AFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYV 359
            .|...:||.:|:..|.||::|......|.||.::|
  Fly   252 TFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFV 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	39/175 (22%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	20/48 (42%)
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	37/160 (23%)
		SH3_STAM	235..288	CDD:212754	20/52 (38%)
		GAT	340..412	CDD:281166
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030