Protein Alignment EndoA and GRB2

DIOPT Version :9

• Sequence 1: NP_001262717.1
• Gene: EndoA / 42265
• FlyBaseID: FBgn0038659
• Length: 369
• Species: Drosophila melanogaster
• Sequence 2: NP_002077.1
• Gene: GRB2 / 2885
• HGNCID: 4566
• Length: 217
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 53/215 - (24%)
• Similarity: 80/215 - (37%)
• Gaps: 80/215 - (37%)

  Fly   218 AEALYDFHSQC--------ADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLN----------- 263
            |.|.|||.:..        .|:|:.|.|...:...:||...::.|:||..:::.
Human     3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPR 67

  Fly   264 --------------------------------------------LDGGG---------GGLNEDG 275
                                                        .||.|         ..||| .
Human    68 AKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNE-L 131

  Fly   276 TPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPC-CQALYDFEPENPGELAFKENDIITLLNRVD 339
            ...|.|:|.|      |:....:....|..|||. .|||:||:|:..|||.|:..|.|.:::..|
Human   132 VDYHRSTSVS------RNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSD 190

  Fly   340 DNWFEGAVNGRTGYFPQSYV 359
            .||::||.:|:||.||::||
Human   191 PNWWKGACHGQTGMFPRNYV 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	9/35 (26%)
		SH3_Endophilin_A	312..361	CDD:212737	23/48 (48%)
GRB2	NP_002077.1	SH3_GRB2_N	1..56	CDD:212879	14/52 (27%)
		SH2_Grb2_like	56..150	CDD:199828	11/100 (11%)
		SH3_GRB2_C	160..212	CDD:212882	24/51 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030