DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and mug137

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_588493.1	Gene:	mug137 / 2539113	PomBaseID:	SPCC1919.11	Length:	420	Species:	Schizosaccharomyces pombe

Alignment Length:	373	Identity:	84/373 - (22%)
Similarity:	155/373 - (41%)	Gaps:	59/373 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 INKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGI 74
            :::...:..||..|.:...|...|:|:|::..:..|.:.:|...|..::.            ..:
pombe     2 VSRFFSWTNEKPLGDQRAHLPDSFLELEQEIAIREEGLSKLFQATTIWID------------SIL 54

  Fly    75 SKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQN 139
            .|:.|:.|........  |.:.|:.:.|:|.:|:| :...|.:.|:|..::.:.:.||....:..
pombe    55 KKVDGEDKEKCLACEN--LGKVMINHSKELPQDSS-YGITLSQLGKANLKIGEHQTSLAYKARVC 116

  Fly   140 FLEPL--HHMQTKDLKEVMHHRKKLQGRRLDFDC---KRRRQAKDD-----EIRGAEDKFGESLQ 194
            :|:.|  :.:|.||....   ||||:.||..::.   |..::.|:|     :||.|..||.||.:
pombe   117 YLDFLKRYLVQAKDFHSA---RKKLESRRQAYESLLQKSFKEKKEDSRLEEDIRLALYKFEESTE 178

  Fly   195 LAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGL---QETL--QEKRSEAESRPRNEF 254
            ..:..|..|.:.:.:...||........:|..:...:|..:   |.:|  |:|...:|....|||
pombe   179 QVKNRMIALKDVEADQYQQLTELIVYELNFFKESTGILNTIFNSQNSLTPQKKIQSSERSVENEF 243

  Fly   255 VPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLP--SPMRSPAKSMAVTPQRQQQPCCQALYDFE 317
            :...:        ...|::..|.:..:...||.|  :|.|...|.....         :|:|.|.
pombe   244 LASPM--------DPSLSKLFTKTTNTEKISPTPFSTPKRKSKKETVFV---------KAIYSFT 291

  Fly   318 PENPGELAFKENDIITLLNRVDDNWFEG-AVN------GRTGYFPQSY 358
            ..|..||.....|:|.:..::..:|:.| .||      |.:|.||.:|
pombe   292 GRNEKELDLHTGDVIQVSEQLGPDWYMGEKVNSKAEKLGNSGMFPVNY 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	52/235 (22%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	17/54 (31%)
mug137	NP_588493.1	BAR_MUG137_fungi	17..230	CDD:153277	50/230 (22%)
mug137	NP_588493.1	SH3	280..341	CDD:214620	17/69 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37723
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52174
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.710