DRSC/TRiP Functional Genomics Resources

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Protein Alignment EndoA and Sh3gl2

DIOPT Version :9

Sequence 1:NP_001262717.1 Gene:EndoA / 42265 FlyBaseID:FBgn0038659 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_062408.2 Gene:Sh3gl2 / 20404 MGIID:700009 Length:352 Species:Mus musculus


Alignment Length:374 Identity:184/374 - (49%)
Similarity:252/374 - (67%) Gaps:29/374 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||.:||.|.::||:|||||||||.||.|||||.|||...|.|:..||.|:|||||.:|
Mouse     1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||::.:..:||:.||.|...|||.|.||||.||.:|::||:|.: |..||.|.|||::::::||.
Mouse    66 AKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCN-FGPALGEVGEAMRELSEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||..:||||::||.::..|||:|:.||.|||:|||||||.|::||.|  |:|:|.|.:||.||.
Mouse   130 SLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            ::|:..||||||.|.|.||||....:|..::|.|...:|:.:...|:|:..:|.|:||.|:.||.
Mouse   195 EIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKP 259

  Fly   259 LLDLNLDGG-----GGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEP 318
            .:.|....|     .|||:..|||              :.|...|       .||||:|||||||
Mouse   260 RMSLEFATGDSTQPNGGLSHTGTP--------------KPPGVQM-------DQPCCRALYDFEP 303

  Fly   319 ENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLPN 367
            ||.|||.|||.|||||.|::|:||:||.::|::|:||.:||::.|.||:
Mouse   304 ENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EndoANP_001262717.1 BAR_Endophilin_A 25..246 CDD:153276 113/222 (51%)
SH3_Endophilin_A 312..361 CDD:212737 32/48 (67%)
Sh3gl2NP_062408.2 Binds and tubulates liposomes. /evidence=ECO:0000250 1..125 70/124 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 16/25 (64%)
Membrane-binding amphipathic helix. /evidence=ECO:0000250 1..21 11/19 (58%)
BAR_Endophilin_A1 25..247 CDD:153297 113/222 (51%)
Required for dimerization upon membrane association. /evidence=ECO:0000250 60..87 11/26 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..289 8/38 (21%)
SH3_Endophilin_A 293..347 CDD:212737 35/53 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 259 1.000 Domainoid score I1976
eggNOG 1 0.900 - - E1_KOG1118
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 363 1.000 Inparanoid score I2164
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52174
OrthoDB 1 1.010 - - D474758at33208
OrthoFinder 1 1.000 - - FOG0000985
OrthoInspector 1 1.000 - - otm44238
orthoMCL 1 0.900 - - OOG6_102270
Panther 1 1.100 - - O PTHR14167
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R571
SonicParanoid 1 1.000 - - X800
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.870

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