DRSC/TRiP Functional Genomics Resources

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Protein Alignment EndoA and Sh3gl2

DIOPT Version :10

Sequence 1:NP_620122.2 Gene:EndoA / 42265 FlyBaseID:FBgn0038659 Length:369 Species:Drosophila melanogaster
Sequence 2:NP_446387.1 Gene:Sh3gl2 / 116743 RGDID:620276 Length:352 Species:Rattus norvegicus


Alignment Length:374 Identity:184/374 - (49%)
Similarity:252/374 - (67%) Gaps:29/374 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||.:||.|.::||:|||||||||.||.|||||.|||...|.|:..||.|:|||||.:|
  Rat     1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            ||::.:..:||:.||.|...|||.|.||||.||.:|::||:|.: |..||.|.|||::::::||.
  Rat    66 AKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCN-FGPALGEVGEAMRELSEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||..:||||::||.::..|||:|:.||.|||:|||||||.|::||.|  |:|:|.|.:||.||.
  Rat   130 SLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            ::|:..||||||.|.|.||||....:|..::|.|...:|:.:...|:|:..:|.|:||.|:.||.
  Rat   195 EIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKP 259

  Fly   259 LLDLNLDGG-----GGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEP 318
            .:.|....|     .|||:..|||               .||      ..:..||||:|||||||
  Rat   260 RMSLEFATGDGTQPNGGLSHTGTP---------------KPA------GVQMDQPCCRALYDFEP 303

  Fly   319 ENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLPN 367
            ||.|||.|||.|||||.|::|:||:||.::|::|:||.:||::.|.||:
  Rat   304 ENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EndoANP_620122.2 BAR_Endophilin_A 25..246 CDD:153276 113/222 (51%)
SH3_Endophilin_A 312..361 CDD:212737 32/48 (67%)
Sh3gl2NP_446387.1 Binds and tubulates liposomes 1..125 70/124 (56%)
Membrane-binding amphipathic helix 1..21 11/19 (58%)
BAR_Endophilin_A1 25..247 CDD:153297 113/222 (51%)
Required for dimerization upon membrane association 60..87 11/26 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..289 17/63 (27%)
SH3_Endophilin_A 293..347 CDD:212737 35/53 (66%)

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