DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and sh3gl3

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_002940145.1	Gene:	sh3gl3 / 100492562	XenbaseID:	XB-GENE-958256	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	195/368 - (52%)
Similarity:	253/368 - (68%)	Gaps:	19/368 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||.:||:|..:||:.||||||||.||.|||||.|:|.::|.||..||.|:|||||..|
Frog     1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDDFQEMERKIDITNKVVAELLSKTTEYLQPNPAYR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            |::..:..:||:.||.|:..|||.||||.:|||.:|::|| |.|.|..||::.||.:||||:||.
Frog    66 ARLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLRHGRELG-DESEFGCALLDAGECMKQMAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||.|:||||::||..:|.|||||:::|.|:|:|||||:|.|:|||.|  |:|||.|.:||.||.
Frog   130 SLDINVKQNFIDPLQSLQDKDLKEILYHLKRLEGRRLDYDYKKRRQGKIPDEEIRQAVEKFEESK 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            :||:..|||.||||.|.||||..|.||..|:|.|.|.:|..|...|..:.:.|.|||:.|...|:
Frog   195 ELAERSMFNFLENDIEQVSQLSVFVEAALDYHRQSAQILEDLHNRLHNRMNTASSRPKRELQHKS 259

  Fly   259 LLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGE 323
            :: ..|: ....|:.:|.||  :||..|..|            .....||||:|||||||||.||
Frog   260 II-ATLE-SNEKLHHNGIPS--NSSIKPSGS------------SGNLDQPCCRALYDFEPENEGE 308

  Fly   324 LAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPLP 366
            |.|||.|||||.|::|:|||||.|||.:|:||.:||:|.||||
Frog   309 LGFKEGDIITLTNQIDENWFEGMVNGESGFFPINYVEVVVPLP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	122/222 (55%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	35/48 (73%)
sh3gl3	XP_002940145.1	BAR_Endophilin_A3	25..247	CDD:153299	122/222 (55%)
sh3gl3	XP_002940145.1	SH3_Endophilin_A	293..347	CDD:212737	38/53 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37723
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2155
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm49415
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080