DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoA and sh3gl1a

DIOPT Version :9

Sequence 1:	NP_001262717.1	Gene:	EndoA / 42265	FlyBaseID:	FBgn0038659	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_005168475.1	Gene:	sh3gl1a / 100005753	ZFINID:	ZDB-GENE-030131-4524	Length:	366	Species:	Danio rerio

Alignment Length:	373	Identity:	182/373 - (48%)
Similarity:	253/373 - (67%)	Gaps:	16/373 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTAR 65
            |:.||||||..||:|.|:||:|||||||||.||.::|||.|:|.:.:.::..||.|:|||||.:|
Zfish     1 MSVAGLKKQFYKASQLMSEKVGGAEGTKLDEDFKDLERKADITSKAISDVLCKTTEYLQPNPASR 65

  Fly    66 AKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKY 130
            |::.....:||:.||.||..|||.||||.||||.||:.:|||.: |..||||.|||:|::|:||.
Zfish    66 ARLTMANTMSKMRGQVKSLGYPQAEGLLGECMLKYGRDMGEDTN-FGGALVEMGEAMKRLAEVKD 129

  Fly   131 SLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAK--DDEIRGAEDKFGESL 193
            |||.::||||::|...:..||||::.||.|||:|||||:|.|::||.|  |:|:|.|.:||.||.
Zfish   130 SLDIDVKQNFIDPFQTIVDKDLKDIQHHLKKLEGRRLDYDYKKKRQGKIADEELRMAMEKFEESR 194

  Fly   194 QLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKT 258
            ..|:..|.|||:.|.|.||||....|:...||.|...||..|...::|:.::|:|:||.:.:|.:
Zfish   195 DAAETSMQNLLDTDVEQVSQLCALVESQLQFHKQSMQVLEELAGAMRERVNKAQSQPRQKRMPVS 259

  Fly   259 LLDLNL---DGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQ---QQPCCQALYDFE 317
            ...::.   :...||.|.       |::|.|..|...:|:.:.|.:.|::   .||||:||||||
Zfish   260 RPSIDYSDPEDSNGGWNP-------SAAAPPSYSSTAAPSFNRASSRQKRNSADQPCCRALYDFE 317

  Fly   318 PENPGELAFKENDIITLLNRVDDNWFEGAVNGRTGYFPQSYVQVQVPL 365
            |||.|||.|.|.|:|||.|::||||:||:..|:||.||.:||:|.|||
Zfish   318 PENEGELGFNEGDVITLTNQIDDNWYEGSFRGQTGLFPCNYVEVMVPL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoA	NP_001262717.1	BAR_Endophilin_A	25..246	CDD:153276	111/222 (50%)
EndoA	NP_001262717.1	SH3_Endophilin_A	312..361	CDD:212737	32/48 (67%)
sh3gl1a	XP_005168475.1	BAR_Endophilin_A	25..247	CDD:153276	111/222 (50%)
sh3gl1a	XP_005168475.1	SH3_Endophilin_A	308..362	CDD:212737	35/53 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2161
eggNOG	1	0.900	-	-		E1_KOG1118
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2238
OMA	1	1.010	-	-		QHG52174
OrthoDB	1	1.010	-	-		D474758at33208
OrthoFinder	1	1.000	-	-		FOG0000985
OrthoInspector	1	1.000	-	-		otm25526
orthoMCL	1	0.900	-	-		OOG6_102270
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X800
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840