DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and BRS3

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001718.1	Gene:	BRS3 / 680	HGNCID:	1113	Length:	399	Species:	Homo sapiens

Alignment Length:	372	Identity:	82/372 - (22%)
Similarity:	167/372 - (44%)	Gaps:	43/372 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSGNGSVLDNVLPDMAHLVNPYWSRFAPMDPMMSKILGLF-TLAIMI-ISCCGNGVVVYIFGGTK 86
            :..:.||:.|      ...|..||  ....|.:..:..:: |.|::| :...||.:::.:|..||
Human    20 TESSSSVVSN------DNTNKGWS--GDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTK 76

  Fly    87 SLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMI 151
            |::|..|:.:.:|||.|..::.:..||...::..|.|:.|.:.|.:.:........||::::.::
Human    77 SMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTIL 141

  Fly   152 AFDRYNVIVKGINGTPMT--IKTSIMKILFIWMMAVFWTVMPLIGWSAYV---PEGNLT--ACSI 209
            :.|||..:||.:...|..  :||.: |...:|::::.:.:...|..:.|.   |..|:|  :|:.
Human   142 SADRYKAVVKPLERQPSNAILKTCV-KAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTS 205

  Fly   210 DYMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLRSSEDCD 274
            ..:::......:.:...|..|..||.:|.. |:.:||...        ....:|:.:...|. ..
Human   206 YPVSKKLLQEIHSLLCFLVFYIIPLSIISV-YYSLIARTL--------YKSTLNIPTEEQSH-AR 260

  Fly   275 KSAEG--KLAKVALTTISLWFMAWTP-YLVICYFGLFKIDGLTP-----LTTIWGATFAKTSAVY 331
            |..|.  ::|:..|..::|:.:.|.| :|:..|........:.|     :.||:....|.:::..
Human   261 KQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCV 325

  Fly   332 NPI-VYGISHPKYRIVLKEKCPMCVFGNTDEPKPDAPASDTETTSEA 377
            ||. :|.:| ..::...|.:...|   ..:.|:|  |.:||..|:.|
Human   326 NPFALYWLS-KSFQKHFKAQLFCC---KAERPEP--PVADTSLTTLA 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	41/177 (23%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	61/277 (22%)
BRS3	NP_001718.1	7tmA_BRS-3	48..341	CDD:320251	66/304 (22%)
		TM helix 1	49..75	CDD:320251	6/25 (24%)
		TM helix 2	82..108	CDD:320251	7/25 (28%)
		TM helix 3	120..150	CDD:320251	6/29 (21%)
		TM helix 4	162..182	CDD:320251	4/20 (20%)
		TM helix 5	214..239	CDD:320251	6/25 (24%)
		TM helix 6	264..294	CDD:320251	7/29 (24%)
		TM helix 7	309..334	CDD:320251	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010