DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rh2 and RHO

DIOPT Version :9

Sequence 1:NP_524398.1 Gene:Rh2 / 42261 FlyBaseID:FBgn0003248 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_000530.1 Gene:RHO / 6010 HGNCID:10012 Length:348 Species:Homo sapiens


Alignment Length:368 Identity:96/368 - (26%)
Similarity:175/368 - (47%) Gaps:34/368 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GPRFQAQSSGNGSVLDNVLPDMAHLVNPY-WSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVY 80
            ||.|....|....|:.          :|: :.::...:|....:|..:...::::....|.:.:|
Human     6 GPNFYVPFSNATGVVR----------SPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY 60

  Fly    81 IFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSI 145
            :....|.||||.|.::||||.:|..|:.......:....:..:|.||..|::.....:|.|.:::
Human    61 VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIAL 125

  Fly   146 WSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSID 210
            ||:.::|.:||.|:.|.::........:||.:.|.|:||:.....||.|||.|:|||...:|.||
Human   126 WSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGID 190

  Fly   211 YMTRM--WNPRSYLITYSLFVYYT-PLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLRSSED 272
            |.|..  .|..|::| |...|::| |:.:|.:.|..::..|  .|.|.::|......|       
Human   191 YYTLKPEVNNESFVI-YMFVVHFTIPMIIIFFCYGQLVFTV--KEAAAQQQESATTQK------- 245

  Fly   273 CDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDG--LTPLTTIWGATFAKTSAVYNPIV 335
                ||.::.::.:..:..:.:.|.||..:.:: :|...|  ..|:.....|.|||::|:|||::
Human   246 ----AEKEVTRMVIIMVIAFLICWVPYASVAFY-IFTHQGSNFGPIFMTIPAFFAKSAAIYNPVI 305

  Fly   336 YGISHPKYR-IVLKEKCPMCVFGNTDEPKPDAPASDTETTSEA 377
            |.:.:.::| .:|...|  |......:.:..|..|.|||:..|
Human   306 YIMMNKQFRNCMLTTIC--CGKNPLGDDEASATVSKTETSQVA 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rh2NP_524398.1 7tm_4 67..>237 CDD:304433 54/172 (31%)
7tm_1 74..336 CDD:278431 77/266 (29%)
RHONP_000530.1 Rhodopsin_N 3..37 CDD:313611 7/40 (18%)
7tmA_MWS_opsin 38..317 CDD:381742 80/293 (27%)
TM helix 1 40..64 CDD:381742 3/23 (13%)
TM helix 2 73..95 CDD:381742 7/21 (33%)
TM helix 3 111..133 CDD:381742 4/21 (19%)
'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343 134..136 0/1 (0%)
TM helix 4 155..171 CDD:381742 5/15 (33%)
TM helix 5 201..224 CDD:381742 7/23 (30%)
TM helix 6 251..273 CDD:381742 3/21 (14%)
TM helix 7 285..310 CDD:381742 10/24 (42%)
Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425 330..348 6/17 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X120
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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