DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rh2 and Opn3

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001178862.1	Gene:	Opn3 / 498289	RGDID:	1594385	Length:	400	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	82/342 - (23%)
Similarity:	153/342 - (44%)	Gaps:	49/342 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 APM-DPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPV 113
            ||: .|...:.|.|....:.::...||.:|:.::.....||||.:|.::||:..|..:.......
  Rat    31 APLFSPTAYERLALLLGCLALLGVGGNLLVLLLYSKFPRLRTPTHLFLVNLSLGDLLVSLFGVTF 95

  Fly   114 MIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKIL 178
            ...:.....||...:.|......|||||.|||.::.::|::||   ::.::...:....:...|.
  Rat    96 TFASCLRNGWVWDAVGCAWDGFSGSLFGFVSITTLTVLAYERY---IRVVHARVINFSWAWRAIT 157

  Fly   179 FIWMMAVFWTVMPLIGWSAYVPEGNLTACSIDYMTRMWNPRSYLITYSLFVYYTPLFLICYSYWF 243
            :||:.::.|...||:||:.|:.:.:...|::|:.::..|..|:::...|.....|:.:|.:.|..
  Rat   158 YIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPMGIIAHCYGH 222

  Fly   244 IIAAVAAHEKAMREQAKKMNVKSLRSSEDCDK-------SAEGKLAKVALTTISLWFMAWTPYLV 301
            |:                .:|:.||..||...       ..|.|:||:......::...|.||:|
  Rat   223 IL----------------YSVRMLRCVEDLQTIQVIKMLRYEKKVAKMCFLMAFVFLTCWMPYVV 271

  Fly   302 ICYFGLFKIDG----LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLKE-------KCPMCV 355
            ..:   ..::|    :||..:|....|||:|.||||::|.....|:|..|.:       :|
  Rat   272 TRF---LVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMIRKFRRSLLQLLCFRLLRC---- 329

  Fly   356 FGNTDEPKPDAPASDTE 372
                ..|..:.||:::|
  Rat   330 ----QRPAKNLPAAESE 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	40/169 (24%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	68/272 (25%)
Opn3	NP_001178862.1	7tm_GPCRs	64..317	CDD:421689	68/274 (25%)
		TM helix 2	74..101	CDD:410628	4/26 (15%)
		TM helix 3	112..142	CDD:410628	12/32 (38%)
		TM helix 4	150..172	CDD:410628	5/21 (24%)
		TM helix 5	197..227	CDD:410628	6/45 (13%)
		TM helix 6	246..276	CDD:410628	8/32 (25%)
		TM helix 7	286..311	CDD:410628	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910