DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and NMBR

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_002502.2	Gene:	NMBR / 4829	HGNCID:	7843	Length:	390	Species:	Homo sapiens

Alignment Length:	327	Identity:	70/327 - (21%)
Similarity:	136/327 - (41%)	Gaps:	47/327 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WSR-FAP------MDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSD 103
            |.| |.|      .:.::..::....|.|:.:...||.::|.||....::|:..|:.:.|||..|
Human    25 WERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGD 89

  Fly   104 FCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPM 168
            ..::.:..||....::::.|:.|.:.|.:..........||::::..::.|||..||     .||
Human    90 LLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIV-----NPM 149

  Fly   169 TIKTS------IMKILFIWMMAVFWTVMPLIGWS-----AYVPEGNLTACSIDY-MTRMWNPRSY 221
            .::||      .:|.:.||:::|...| |...:|     :.:...:.||| |.| .|...:|:.:
Human   150 DMQTSGALLRTCVKAMGIWVVSVLLAV-PEAVFSEVARISSLDNSSFTAC-IPYPQTDELHPKIH 212

  Fly   222 LITYSLFVYYTPLFLICYSYWFIIAAV--AAHE--KAMREQAKKMNVKSLRSSEDCDKSAEGKLA 282
            .:...|..:..||.:|...|:.|...:  :||.  ....|..||            ......:||
Human   213 SVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKK------------QMETRKRLA 265

  Fly   283 KVALTTISLWFMAWTPYLVICYFGLFKIDGLTP-----LTTIWGATFAKTSAVYNPIVYGISHPK 342
            |:.|..:..:...|.|..::..:..|..:.:.|     :.|:.....:..::..||....:....
Human   266 KIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSES 330

  Fly   343 YR 344
            :|
Human   331 FR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	45/181 (25%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	63/282 (22%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
NMBR	NP_002502.2	7tm_1	60..322	CDD:278431	62/280 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010