DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and rho

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_571159.1	Gene:	rho / 30295	ZFINID:	ZDB-GENE-990415-271	Length:	354	Species:	Danio rerio

Alignment Length:	373	Identity:	100/373 - (26%)
Similarity:	175/373 - (46%)	Gaps:	39/373 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPRFQAQSSGNGSVLDNVLPDMAHLVNPY-WSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVY 80
            ||.|....|....|:.          :|| :.::..:.|.....:..:...::|.....|.:.:|
Zfish     6 GPAFYVPMSNATGVVR----------SPYEYPQYYLVAPWAYGFVAAYMFFLIITGFPVNFLTLY 60

  Fly    81 IFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSI 145
            :....|.||||.|.::||||.:|..|:.......:....:..:|.|.|.|::.....:|.|.:.:
Zfish    61 VTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLGGEMGL 125

  Fly   146 WSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSID 210
            .|:.::|.:|:.|:.|.::........:||.:.|.|:||....|.||:|||.|:|||...:|.:|
Zfish   126 KSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWSRYIPEGMQCSCGVD 190

  Fly   211 YMTRM--WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLRSSEDC 273
            |.||.  .|..|::|...:..::.||.:|.:.|..::..|   ::|.|:|         :.||..
Zfish   191 YYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTV---KEAARQQ---------QESETT 243

  Fly   274 DKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDG--LTPLTTIWGATFAKTSAVYNPIVY 336
            .: ||.::.::.:..:..:.:.|.||..:.:: :|...|  ..|:.....|.||||||||||.:|
Zfish   244 QR-AEREVTRMVIIMVIAFLICWLPYAGVAWY-IFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIY 306

  Fly   337 GISHPKYRIVLKEKC---PMCVFGNTDEPKPDA--PASDTETTSEADS 379
            ...:.::|     .|   .:|...|..|.:..|  .||.||.:|.:.|
Zfish   307 ICMNKQFR-----HCMITTLCCGKNPFEEEEGASTTASKTEASSVSSS 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	52/171 (30%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	78/265 (29%)
rho	NP_571159.1	Rhodopsin_N	2..37	CDD:287397	8/40 (20%)
		7tm_4	45..323	CDD:304433	82/296 (28%)
		7tm_1	55..306	CDD:278431	78/264 (30%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000250\|UniProtKB:P02699	134..136		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354		7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910