DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and GRPR

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_005305.1	Gene:	GRPR / 2925	HGNCID:	4609	Length:	384	Species:	Homo sapiens

Alignment Length:	341	Identity:	83/341 - (24%)
Similarity:	143/341 - (41%)	Gaps:	59/341 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NVLPDMAHL-VNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLV 96
            |:....|.| ||..||.     |.:..::......|::|...||..::.||...||:|...||.:
Human    20 NISSHSADLPVNDDWSH-----PGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFI 79

  Fly    97 LNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVK 161
            .:||..|..::.:.:||....:..:.|:.|.:.|.:..........||::::..::.|||..||:
Human    80 SSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVR 144

  Fly   162 GINGTPMTIKTS--IMKI----LFIWMM--------AVFWTVMPLIGWSAYVPEGNLT--ACSID 210
                 ||.|:.|  :|||    .|||::        |||..:.|.     :....|.|  :|:..
Human   145 -----PMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPF-----HEESTNQTFISCAPY 199

  Fly   211 YMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNV-------KSLR 268
            ..:...:|:.:.:...|..|..||.:|...|:||       .|.:.:.|..:.|       |.:.
Human   200 PHSNELHPKIHSMASFLVFYVIPLSIISVYYYFI-------AKNLIQSAYNLPVEGNIHVKKQIE 257

  Fly   269 SSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLF---KIDG--LTPLTTIWGATFAKTS 328
            |.:        :|||..|..:.|:...|.|..||..:..:   ::|.  |..:|:|.....|.|:
Human   258 SRK--------RLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTN 314

  Fly   329 AVYNPIVYGISHPKYR 344
            :..||....:....:|
Human   315 SCVNPFALYLLSKSFR 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	48/185 (26%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	72/289 (25%)
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	75/315 (24%)
		TM helix 1	42..68	CDD:320252	6/25 (24%)
		TM helix 2	75..101	CDD:320252	7/25 (28%)
		TM helix 3	113..143	CDD:320252	6/29 (21%)
		TM helix 4	155..175	CDD:320252	6/19 (32%)
		TM helix 5	207..232	CDD:320252	7/24 (29%)
		TM helix 6	257..287	CDD:320252	10/37 (27%)
		TM helix 7	301..326	CDD:320252	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100