DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and Rho

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	XP_038962987.1	Gene:	Rho / 24717	RGDID:	3573	Length:	358	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	92/341 - (26%)
Similarity:	164/341 - (48%)	Gaps:	33/341 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIIN 117
            :|....:|..:...::::....|.:.:|:....|.||||.|.::||||.:|..|:.......:..
  Rat    33 EPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYT 97

  Fly   118 FYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWM 182
            ..:..:|.||..|::.....:|.|.:.:||:.::|.:||.|:.|.::........:||.:.|.|:
  Rat    98 SLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWV 162

  Fly   183 MAVFWTVMPLIGWSA----------YVPEGNLTACSIDYMTRM--WNPRSYLITYSLFVYYT-PL 234
            ||:.....||:|||:          |:|||...:|.|||.|..  .|..|::| |...|::| |:
  Rat   163 MALACAAPPLVGWSSVFSPCFITLRYIPEGMQCSCGIDYYTLKPEVNNESFVI-YMFVVHFTIPM 226

  Fly   235 FLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLRSSEDCDKSAEGKLAKVALTTISLWFMAWTPY 299
            .:|.:.|..::..|  .|.|.::|......|           ||.::.::.:..:..:.:.|.||
  Rat   227 IVIFFCYGQLVFTV--KEAAAQQQESATTQK-----------AEKEVTRMVIIMVIFFLICWLPY 278

  Fly   300 LVICYFGLFKIDG--LTPLTTIWGATFAKTSAVYNPIVYGISHPKYR-IVLKEKCPMCVFGNTDE 361
            ..:..: :|...|  ..|:.....|.||||:::||||:|.:.:.::| .:|...|  |......:
  Rat   279 ASVAMY-IFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTTLC--CGKNPLGD 340

  Fly   362 PKPDAPASDTETTSEA 377
            .:..|.||.|||:..|
  Rat   341 DEASATASKTETSQVA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	54/182 (30%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	78/276 (28%)
Rho	XP_038962987.1	Rhodopsin_N	3..37	CDD:313611	1/3 (33%)
		7tmA_MWS_opsin	38..327	CDD:381742	81/303 (27%)
		TM helix 1	40..64	CDD:381742	3/23 (13%)
		TM helix 2	73..95	CDD:381742	7/21 (33%)
		TM helix 3	111..133	CDD:381742	4/21 (19%)
		TM helix 4	155..171	CDD:381742	5/15 (33%)
		TM helix 5	211..234	CDD:381742	7/23 (30%)
		TM helix 6	261..283	CDD:381742	3/21 (14%)
		TM helix 7	295..320	CDD:381742	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910