DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and Gpr151

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_853521.1	Gene:	Gpr151 / 240239	MGIID:	2441887	Length:	422	Species:	Mus musculus

Alignment Length:	382	Identity:	86/382 - (22%)
Similarity:	141/382 - (36%)	Gaps:	93/382 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PMMSK----ILGLFTLAIMIISCCGNGVVVYIF--GGTKSLRTPANLLVLNLAFSDFCMMASQSP 112
            |..||    |:....:|:.::...||..|:.|.  |..|...:..:.|:|||:.:||.::...:|
Mouse    33 PSDSKDWRTIIPSLLMAVCLVGLVGNLCVIGILLHGVWKRKPSTIHSLILNLSLADFSLLLFSAP 97

  Fly   113 VMIINFYYETWVLGPLWCDIYAGCGSLFGCVSI-W--SMCMIAFDRYNVIVK----GINGTPMTI 170
            |....:....|.||  |          |.|.|. |  .:||.|.....|:|.    .....|  .
Mouse    98 VRAAAYSKGVWDLG--W----------FICKSSDWFTHVCMAAKSLTFVVVAKACFAYASDP--A 148

  Fly   171 KTSIMKILFIW-MMAVFWTV---MPLIGW--SAYVPEGNLTACSID-------YMTRMWNPRSYL 222
            |...:....|| ::|..|.|   :||..|  |.......:..|.:|       :|:....
Mouse   149 KQESIHSRTIWSVLAGIWVVASLLPLPEWLFSTTRRHAGVEMCLVDVPAVAEEFMSMFGK----- 208

  Fly   223 ITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVK-SLRSSEDCDKSAEGKLAKVAL 286
             .|.|.|:..||.|....:|      .|:::......|..|:: .:||     |.....|...|:
Mouse   209 -LYPLLVFCLPLLLAGVYFW------RAYDQCKTRCTKTRNLRDQMRS-----KQLTVMLLSTAI 261

  Fly   287 TTISLWFMAWTPYLVICYF---GLFKIDGLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLK 348
            .:..||...|..:|.:.:.   |.....|...|:.:  ..|..::|  ||:::.:...:::..||
Mouse   262 ISALLWLPEWIAWLWVWHVKAGGPMPPQGFIALSQV--LMFFTSTA--NPLIFLVMSEEFKAGLK 322

  Fly   349 -----------------EKCPMCVFGNTDEPKPDAPASDTETT--------SEADSK 380
                             ::.|.   |||:.....||:.:|:|.        |..|||
Mouse   323 GLWKWMITRKPAVTSEVQEAPA---GNTEALPGKAPSPETQTCILDTDGRGSPDDSK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	46/191 (24%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	67/287 (23%)
Gpr151	NP_853521.1	7tmA_GPR151	42..321	CDD:320133	69/313 (22%)
		TM helix 1	42..68	CDD:320133	6/25 (24%)
		TM helix 2	77..102	CDD:320133	8/24 (33%)
		TM helix 3	114..144	CDD:320133	8/29 (28%)
		TM helix 4	157..178	CDD:320133	7/20 (35%)
		TM helix 5	203..232	CDD:320133	9/40 (23%)
		TM helix 6	247..277	CDD:320133	9/34 (26%)
		TM helix 7	289..314	CDD:320133	6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..422		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100