DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and OPN3

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_055137.2	Gene:	OPN3 / 23596	HGNCID:	14007	Length:	402	Species:	Homo sapiens

Alignment Length:	351	Identity:	91/351 - (25%)
Similarity:	168/351 - (47%)	Gaps:	44/351 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PDMAHLVNPYWSRFAPM-DPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNL 99
            |..|..::|     ||: .|...:.|.|...:|.::....|.:|:.::...:.||||.:||::|:
Human    24 PAPAGTLSP-----APLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNI 83

  Fly   100 AFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAG-CGSLFGCVSIWSMCMIAFDRYNVIVKGI 163
            :.||..:.........::.....||...:.| ::.| .|||||.|||.::.::|::||   ::.:
Human    84 SLSDLLVSLFGVTFTFVSCLRNGWVWDTVGC-VWDGFSGSLFGIVSIATLTVLAYERY---IRVV 144

  Fly   164 NGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSIDYMTRMWNPRSYLITYSLF 228
            :...:....:...|.:||:.::.|...||:||:.|:.:.:...|::|:.::..|..|:::...|.
Human   145 HARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLG 209

  Fly   229 VYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLRSSEDCDK-------SAEGKLAKVAL 286
            ....||.:|.:.|..|:                .:::.||..||...       ..|.||||:..
Human   210 CLVVPLGVIAHCYGHIL----------------YSIRMLRCVEDLQTIQVIKILKYEKKLAKMCF 258

  Fly   287 TTISLWFMAWTPYLVICYFGLFKIDG----LTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVL 347
            ..|..:.:.|.||:|||:   ..::|    :||..:|....|||::.||||::|.....|:|..|
Human   259 LMIFTFLVCWMPYIVICF---LVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSL 320

  Fly   348 KEKCPMCV-FGNTDEPKPDAPASDTE 372
            .:.  :|: ......|..|.||:.:|
Human   321 LQL--LCLRLLRCQRPAKDLPAAGSE 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	43/170 (25%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	72/273 (26%)
OPN3	NP_055137.2	7tmA_Encephalopsin	58..316	CDD:320206	73/280 (26%)
		TM helix 2	76..103	CDD:320206	5/26 (19%)
		TM helix 3	114..144	CDD:320206	13/33 (39%)
		TM helix 4	152..174	CDD:320206	5/21 (24%)
		TM helix 5	199..229	CDD:320206	7/45 (16%)
		TM helix 6	248..278	CDD:320206	12/32 (38%)
		TM helix 7	288..313	CDD:320206	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910