DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and Rho

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_663358.1	Gene:	Rho / 212541	MGIID:	97914	Length:	348	Species:	Mus musculus

Alignment Length:	331	Identity:	91/331 - (27%)
Similarity:	165/331 - (49%)	Gaps:	23/331 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIIN 117
            :|....:|..:...::::....|.:.:|:....|.||||.|.::||||.:|..|:.......:..
Mouse    33 EPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYT 97

  Fly   118 FYYETWVLGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWM 182
            ..:..:|.||..|::.....:|.|.:::||:.::|.:||.|:.|.::........:||.::|.|:
Mouse    98 SLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVVFTWI 162

  Fly   183 MAVFWTVMPLIGWSAYVPEGNLTACSIDYMTRM--WNPRSYLITYSLFVYYT-PLFLICYSYWFI 244
            ||:.....||:|||.|:|||...:|.|||.|..  .|..|::| |...|::| |:.:|.:.|..:
Mouse   163 MALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVI-YMFVVHFTIPMIVIFFCYGQL 226

  Fly   245 IAAVAAHEKAMREQAKKMNVKSLRSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFK 309
            :..|  .|.|.::|......|           ||.::.::.:..:..:.:.|.||..:.:: :|.
Mouse   227 VFTV--KEAAAQQQESATTQK-----------AEKEVTRMVIIMVIFFLICWLPYASVAFY-IFT 277

  Fly   310 IDG--LTPLTTIWGATFAKTSAVYNPIVYGISHPKYR-IVLKEKCPMCVFGNTDEPKPDAPASDT 371
            ..|  ..|:.....|.|||:|::|||::|.:.:.::| .:|...|  |......:....|.||.|
Mouse   278 HQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLC--CGKNPLGDDDASATASKT 340

  Fly   372 ETTSEA 377
            ||:..|
Mouse   341 ETSQVA 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	54/172 (31%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	77/266 (29%)
Rho	NP_663358.1	Rhodopsin_N	3..37	CDD:313611	1/3 (33%)
		7tmA_MWS_opsin	38..317	CDD:320208	80/293 (27%)
		TM helix 1	39..65	CDD:320208	3/25 (12%)
		TM helix 2	72..99	CDD:320208	7/26 (27%)
		TM helix 3	110..140	CDD:320208	9/29 (31%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000250\|UniProtKB:P02699	134..136		0/1 (0%)
		TM helix 4	151..173	CDD:320208	7/21 (33%)
		TM helix 5	200..230	CDD:320208	8/30 (27%)
		TM helix 6	245..275	CDD:320208	6/41 (15%)
		TM helix 7	285..310	CDD:320208	10/24 (42%)
		Interaction with SAG. /evidence=ECO:0000250\|UniProtKB:P02699	330..348		7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910