DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and npr-1

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_508816.1	Gene:	npr-1 / 180752	WormBaseID:	WBGene00003807	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	101/391 - (25%)
Similarity:	172/391 - (43%)	Gaps:	87/391 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLN 98
            |.||      |..|.:| :.|.::..|.||.|.:.     ||..::|:....|:|.:..|:.:||
Worm    15 VYPD------PSQSIYA-IVPFLTVYLFLFFLGLF-----GNVTLIYVTCSHKALLSVQNIFILN 67

  Fly    99 LAFSDFCMMASQS-PVMIINFYYETWVLGPLWCDIYAGC--G-SLFGCVSIWSMCMIAFDRYNVI 159
            ||.|| |||...| |:..|...|:.|..|.|.|.:.. |  | |:|.|.  :|:..||.|||.::
Worm    68 LAASD-CMMCILSLPITPITNVYKNWYFGNLLCHLIP-CIQGISIFVCT--FSLGAIALDRYILV 128

  Fly   160 VKGINGTPMTIKTSIMKILFIWMMAVFWTV-----MPLIGWSAYVPEGNLTACSIDYMTRMW--- 216
            |:. :.||::.:.:.:..:.:|:::...|:     |.:|   .|..|   ..|.. :.|..|
Worm   129 VRP-HSTPLSQRGAFLTTVLLWILSFVVTLPYAFNMQMI---EYTEE---RICGY-FCTEKWESA 185

  Fly   217 -NPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKM--NVKSLRSS-------- 270
             :.|:|.:...|..:..|..::.:.|..|::.::   |..:.:.:||  ...:|.||
Worm   186 KSRRAYTMIVMLAQFVVPFAVMAFCYANIVSVLS---KRAQTKIRKMVERTSALESSCAFPSHGL 247

  Fly   271 --------EDCDKSAEGKLAKV--------ALTTISLWF-MAWTPYLVI----------CYFGLF 308
                    |..||..:.|...|        .|.|:.:|| :.|.|:.||          .:|.|:
Worm   248 EQYENELNEFLDKQEKEKQRVVLQNRRTTSILVTMVVWFGITWLPHNVISLIIEYDDTQSFFRLY 312

  Fly   309 KID--GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYR-IVLKEKCPMCVFGNTDEPKPDAPASD 370
            ..|  .::.|..::..:.|.::.|.||::|...:|.:| :|:|     ..||  |..|.|...:.
Worm   313 GRDDYDISYLLNLFTHSIAMSNNVLNPVLYAWLNPSFRQLVIK-----TYFG--DRRKSDRIINQ 370

  Fly   371 T 371
            |
Worm   371 T 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	50/182 (27%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	79/313 (25%)
npr-1	NP_508816.1	7tmA_NPYR-like	27..351	CDD:320331	86/343 (25%)
		TM helix 1	29..53	CDD:320331	7/28 (25%)
		TM helix 2	62..84	CDD:320331	12/22 (55%)
		TM helix 3	100..122	CDD:320331	7/24 (29%)
		TM helix 4	143..159	CDD:320331	2/15 (13%)
		TM helix 5	189..212	CDD:320331	4/22 (18%)
		TM helix 6	273..298	CDD:320331	8/24 (33%)
		TM helix 7	321..346	CDD:320331	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6646
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860