DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh2 and GPR151

DIOPT Version :9

Sequence 1:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_919227.2	Gene:	GPR151 / 134391	HGNCID:	23624	Length:	419	Species:	Homo sapiens

Alignment Length:	409	Identity:	90/409 - (22%)
Similarity:	151/409 - (36%)	Gaps:	110/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AQSSGNGSVLDNVLPDMAHLVNPYWSRFAPMDPM-MSKILGLFTLAIMIISCCGNGVVVYIF--G 83
            |.:..|.|.: ||  ..|||  .:...:.|.|.. ...|:....:|:.::...||..|:.|.  .
Human     5 AFADSNSSSM-NV--SFAHL--HFAGGYLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHN 64

  Fly    84 GTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSI-WS 147
            ..|...:..:.|:|||:.:|..::...:|:....:....|.||  |          |.|.|. |.
Human    65 AWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKSVWDLG--W----------FVCKSSDWF 117

  Fly   148 M--CMIAFDRYNVIVKGINGTPMTIKTSIMKILF----------------IW-MMAVFWTV---M 190
            :  ||.|.....|:|              .|:.|                || ::...|||   :
Human   118 IHTCMAAKSLTIVVV--------------AKVCFMYASDPAKQVSIHNYTIWSVLVAIWTVASLL 168

  Fly   191 PLIGW--SAYVPEGNLTACSID-------YMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIA 246
            ||..|  |.......:..|.:|       :|:....      .|.|..:..|||...:.:|
Human   169 PLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGK------LYPLLAFGLPLFFASFYFW---- 223

  Fly   247 AVAAHEKAMREQAKKMNVKS-LRSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYF---GL 307
              .|:::..:...|..|::: :||     |.....|..:|:.:..||...|..:|.:.:.   |.
Human   224 --RAYDQCKKRGTKTQNLRNQIRS-----KQVTVMLLSIAIISALLWLPEWVAWLWVWHLKAAGP 281

  Fly   308 FKIDGLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLK-------EKCPMCV-------FGN 358
            ....|...|:.:  ..|:.:||  ||:::.:...::|..||       .|.|..|       .||
Human   282 APPQGFIALSQV--LMFSISSA--NPLIFLVMSEEFREGLKGVWKWMITKKPPTVSESQETPAGN 342

  Fly   359 TD-----EPKPDAPASDTE 372
            ::     .|.|::|||..|
Human   343 SEGLPDKVPSPESPASIPE 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	43/203 (21%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	64/299 (21%)
GPR151	NP_919227.2	7tmA_GPR151	38..317	CDD:320133	67/325 (21%)
		TM helix 1	38..64	CDD:320133	6/25 (24%)
		TM helix 2	73..98	CDD:320133	6/24 (25%)
		TM helix 3	110..140	CDD:320133	10/43 (23%)
		TM helix 4	153..174	CDD:320133	7/20 (35%)
		TM helix 5	199..228	CDD:320133	8/40 (20%)
		TM helix 6	243..273	CDD:320133	9/34 (26%)
		TM helix 7	285..310	CDD:320133	7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..419		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100