Protein Alignment Octalpha2R and 5-HT7

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 715
• Identity: 183/715 - (25%)
• Similarity: 268/715 - (37%)
• Gaps: 273/715 - (38%)

  Fly    24 FSTGKPDNATLNPPLLSVDGQLTLPPGSGYVNVNDTIFFL------------NGSFYNSSLQLAA 76
            ::.||   ||:..||  |:|:........:   |.:..||            :||...|.....:
  Fly    48 YAAGK---ATVPAPL--VEGETESATSQDF---NSSSAFLGAIASASSTGSGSGSGSGSGSGSGS 104

  Fly    77 GFYNQSSAS----------GATSGNLTNPNHTEVHWDG------RYPSGY----TLTHIVIASII 121
            |.|..:|.:          |.||.||.:.|.|.|....      .:.:|.    .||.|.: ||:
  Fly   105 GSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFV-SIV 168

  Fly   122 VTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSW 186
            :.|:::..||||:||.||:...:.|:...|:.:.|||::|..:.|::||.:|..|::..|.||..
  Fly   169 LLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPL 233

  Fly   187 WCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPL 251
            .|||..:.|||.|||||:|||.||:|||.:|||.::|...|||.|..:.:..||:.:|.|.:|||
  Fly   234 LCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPL 298

  Fly   252 --LGWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPR 314
              ||.:.:..||. |.|.:.::..|.:|:.|||||||..:|:|||.:|:.||
  Fly   299 LILGNEHEDEEGQ-PICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAA------------- 349

  Fly   315 KTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDIS 379
                                              |:|.
  Fly   350 ----------------------------------RRIV--------------------------- 353

  Fly   380 TSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGL 444
                  ||...|||.|..|             .:|.|.|.|...||....|.
  Fly   354 ------LEEKRAQTHLQQA-------------LNGTGSPSAPQAPPLGHTEL------------- 386

  Fly   445 NVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGG---GNGSAVATPGGLQQTGGNELRVSPIAG 506
                 .|.|:....:.:.|.:.|.:..||.::.||   |:||.    ||:
  Fly   387 -----ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSG----GGV--------------- 427

  Fly   507 RCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQ 571
                                |..:|::.
  Fly   428 --------------------SGSTGLLG------------------------------------- 435

  Fly   572 QSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSF 636
                                                 .|..:|.|....|||:|:..||:||.:|
  Fly   436 -------------------------------------SPHHKKLRFQLAKEKKASTTLGIIMSAF 463

  Fly   637 IACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFKXC 701
            ..||||||.|.::.|..:.|  :|.|..::..||||.||.|||.||...|:|||:.|:.||:..|
  Fly   464 TVCWLPFFILALIRPFETMH--VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526

  Fly   702  701
              Fly   527  526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	76/184 (41%)
		7tm_4	133..>252	CDD:304433	53/120 (44%)
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	73/169 (43%)
		7tm_1	179..507	CDD:278431	139/554 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940